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  1. A Phase 1, Multicenter, Open-Label, Dose-Escalation and Expansion, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-120 in Subjects with Advanced Hematologic Malignancies with an IDH1 Mutation

    ... study. Subjects must have ECOG PS of 0 to 2. Platelet count ≥20,000/µL (Transfusions to achieve this level are ...

    Clinical Trial last updated 02/22/2017 - 11:21am.

  2. HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy (RAFA)

    ... and at least one of the following features: Platelet count <20 x 109/L or platelet transfusion dependence* ANC <1000 x 109/L Hgb <8 gm/dl or ...

    Clinical Trial last updated 05/09/2016 - 3:19pm.

  3. Acute Myeloid Leukemia (AML)

    ... from anemia and a risk of bleeding from a low platelet count. There is also an increased risk of infection, since ... bleeding and easy bruising caused by a very low platelet count called thrombocytopenia , which may also include the ...

    Topic section last updated 07/07/2016 - 3:15pm.

  4. Growth Factors

    ... Platelet Growth Factor Platelet growth factor is called thrombopoietin. It is a ...

    Topic section last updated 04/06/2016 - 12:37pm.

  5. My MDS Diagnosis and Progression of Treatment

    ... doctor.  First thing was lab work, which showed a high platelet count.  Within a few days, I was sent to a hematologist ... I was able to stop all medication for a month when the platelet count was stable.  Johns Hopkins is now managing my cancer care with ...

    Patient Chronicle last updated 12/15/2016 - 11:19am.

  6. Types

    ... RT (Refractory Thrombocytopenia ) – Low platelet count Less than 5 percent young blood ... Low white blood cell count (neutropenia) or low platelet count (thrombocytopenia) Dysplasia in more than 1 ...

    Topic section last updated 11/14/2016 - 1:11pm.

  7. Pregnancy in Bone Marrow Failure Disease

    ... Other complications include the need for blood and platelet transfusions, anticoagulation with blood thinners, thromboses ...

    Interview last updated 01/13/2017 - 9:28am.

  8. Eculizumab in Pregnant Patients with Paroxysmal Nocturnal Hemoglobinuria

    ... pregnancy to 0.92 units per month during pregnancy. Platelet transfusions were given in 16 pregnancies. In 54% of pregnancies ...

    Research Article last updated 10/12/2015 - 10:05am.

  9. Ruxolitinib Phosphate in Treating Patients With Chronic Neutrophilic Leukemia or Atypical Chronic Myeloid Leukemia

    ... 90 days of day 1, cycle one Subjects must have platelet count greater than 25,000 per microliter at baseline and at the ... requiring therapeutic doses of anticoagulation or anti- platelet therapies (aspirin above 81 mg daily, Plavix or similar agents) ...

    Clinical Trial last updated 06/06/2016 - 2:18pm.

  10. Thrombopoiesis-stimulating agents and myelodysplastic syndromes

    ... to reduce bleeding events, decrease dependency on platelet transfusions and extend exposure to disease-modifying therapies. ...

    Research Article last updated 03/04/2015 - 10:20am.