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  1. Efficacy and Safety of Eltrombopag In Patients With Severe and Very Severe Aplastic Anemia

    ... aplastic anemia will result in an increase in platelet counts. The investigators hypothesize that in patients with ... anemia, treatment with eltrombopag will lead to fewer platelet transfusions, red blood cell transfusions, and fewer bleeding ...

    Clinical Trial last updated 04/25/2016 - 10:42am.

  2. A Pilot Study of a Thrombopoietin-Receptor Agonist, Eltrombopag, in Patients With Low to Int-2 Risk Myelodysplastic Syndrome (MDS)

    ... red blood cell , white blood cell , and platelet counts). Patients with MDS are at risk for symptomatic anemia, ... therapies require regular, expensive, and inconvenient platelet transfusions, and are at risk for further serious bleeding ...

    Clinical Trial last updated 04/28/2016 - 12:35pm.

  3. ASH 2012 - Reviewing MDS Progress from Research and Clinical Perspectives

    ... purpura (ITP). Patients with ITP have a low platelet count, not because of a bone marrow problem, but due to an ... earlier studied in patients with MDS who also have a low platelet count and in the largest study, it was found that romiplostin did improve platelet counts in about 40 to 50% of MDS patients with low platelet counts.  ...

    Interview last updated 02/07/2013 - 1:28pm.

  4. Growth Factors in Aplastic Anemia, MDS, and PNH: Current Thinking on their Use, Risks, and Benefits

    ... red blood cell , white blood cell , or platelet counts. In this webinar, Dr. Akhtari will discuss the role and biology of red blood cells, white blood cells, and platelet growth factors in patients with aplastic anemia , MDS, and PNH ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  5. Pregnancy in Bone Marrow Failure Disease

    ... Other complications include the need for blood and platelet transfusions, anticoagulation with blood thinners, thromboses ...

    Interview last updated 01/13/2017 - 9:28am.

  6. Extended Dosing With Eltrombopag for Severe Aplastic Anemia

    ... from infection or bleeding, and they require regular platelet and/or red blood cell transfusions, which are expensive ... was first identified as the principal protein regulating platelet production, and it stimulates the proliferation of megakaryocytes and ...

    Clinical Trial last updated 04/26/2016 - 9:36am.

  7. Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of thrombopoietin receptor agonists in aplastic anemia and myelodysplastic syndromes.

    ... causes for complications in both diseases. Blood and platelet transfusions are frequently necessary, but transfusions are ... TPOR is not only expressed on megakaryocytes (the platelet forming cells) but also on bone marrow stem cells that give ...

    Research Review last updated 05/02/2016 - 9:21am.

  8. Moderate, Severe, and Very Severe Aplastic Anemia: How are treatment decisions made?

    ... and may feel fine even though they have a low platelet count -- it can be more difficult to get them to understand there ... and may feel fine even though they have a low platelet count -- it can be more difficult to get them to understand there are ...

    Interview last updated 10/14/2015 - 12:47pm.

  9. Special Issues for People with PNH

    ... Can cause serious bleeding in people with a low platelet count; platelet transfusions may be needed before surgery. If you do have ...

    Page last updated 01/20/2015 - 4:59pm.

  10. Eltrombopag: Recent Discoveries on Potential New Applications for Aplastic Anemia

    ... and destroys them very quickly, resulting in low platelet counts. Eltrombopag (Promacta®) was originally developed to ... tested in this setting, it was found to not only improve platelet counts in some patients, but also improve white and red blood cell ...

    Interview last updated 02/14/2014 - 2:01pm.