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  1. Symptoms

    ... Low Platelet Counts A low platelet count is called thrombocytopenia . If you have a low ...

    Topic section last updated 03/29/2016 - 6:18pm.

  2. A Pilot Study of a Thrombopoietin-Receptor Agonist, Eltrombopag, in Patients With Low to Int-2 Risk Myelodysplastic Syndrome (MDS)

    ... red blood cell , white blood cell , and platelet counts). Patients with MDS are at risk for symptomatic anemia, ... therapies require regular, expensive, and inconvenient platelet transfusions, and are at risk for further serious bleeding ...

    Clinical Trial last updated 04/28/2016 - 12:35pm.

  3. Overlap Syndromes: When PNH Appears with Aplastic Anemia or MDS

    ... marrow), a chronically high white blood cell or platelet count, especially if they have the JAK2 mutation . Does ... may not be not be able to receive anticoagulants if their platelet count is low. Conversely, for a PNH/aplastic anemia patient, there ...

    Interview last updated 05/14/2015 - 1:53pm.

  4. Growth Factors in Aplastic Anemia, MDS, and PNH: Current Thinking on their Use, Risks, and Benefits

    ... red blood cell , white blood cell , or platelet counts. In this webinar, Dr. Akhtari will discuss the role and biology of red blood cells, white blood cells, and platelet growth factors in patients with aplastic anemia , MDS, and PNH ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  5. ASH 2012 - Reviewing MDS Progress from Research and Clinical Perspectives

    ... purpura (ITP). Patients with ITP have a low platelet count, not because of a bone marrow problem, but due to an ... earlier studied in patients with MDS who also have a low platelet count and in the largest study, it was found that romiplostin did improve platelet counts in about 40 to 50% of MDS patients with low platelet counts.  ...

    Interview last updated 02/07/2013 - 1:28pm.

  6. Extended Dosing With Eltrombopag for Severe Aplastic Anemia

    ... from infection or bleeding, and they require regular platelet and/or red blood cell transfusions, which are expensive ... was first identified as the principal protein regulating platelet production, and it stimulates the proliferation of megakaryocytes and ...

    Clinical Trial last updated 04/26/2016 - 9:36am.

  7. REVERSE 1 INCB 18424-271

    ... supplementation is allowed. Evidence of platelet engraftment (ie, platelets ≥ 20 × 10^9/L) ...

    Clinical Trial last updated 12/14/2016 - 11:24am.

  8. My Son's Aplastic Anemia -- A Mother's Account

    ... globulin (ATG). At this point he had several platelet transfusions, as well as some red blood cell transfusions. ...

    Patient Chronicle last updated 12/15/2016 - 11:21am.

  9. A Phase I Study to Assess the Safety APL-2 as an Add-On to Standard of Care in Subjects With PNH

    ... one transfusion within 12 months prior to screening Platelet count of >30,000/mm3 Absolute neutrophil count > ...

    Clinical Trial last updated 08/24/2016 - 11:15am.

  10. Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of thrombopoietin receptor agonists in aplastic anemia and myelodysplastic syndromes.

    ... causes for complications in both diseases. Blood and platelet transfusions are frequently necessary, but transfusions are ... TPOR is not only expressed on megakaryocytes (the platelet forming cells) but also on bone marrow stem cells that give ...

    Research Review last updated 05/02/2016 - 9:21am.