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  1. Red Blood Cell Transfusion Dependency and Hyperferritinemia Are Associated with Impaired Survival in Patients Diagnosed with Myelodysplastic Syndromes: Results from the First Polish MDS-PALG Registry

    ... are the only treatment option for about 40% of patients. Transfusion-dependent patients develop secondary iron overload . The ... RBC-transfusion dependence (p = 0.0033; HR 2.67L), platelet transfusion dependence (p = 0.0071; HR 3.321), hemoglobin ...

    Research Article last updated 10/06/2016 - 1:01pm.

  2. Retired MDS Patient Living Life to the Fullest Since Transplant

    ... hospital, where I had several more red blood cell and platelet transfusions.  During the first ten months of chemotherapy, ... and they had to use a needle in my veins for every test and transfusion. I became resistant to the platelets and had to have special ...

    Patient Chronicle last updated 04/26/2018 - 10:43am.

  3. Treatments

    ... A blood transfusion is a safe and common procedure. Most people who have a bone ... red blood cell , white blood cell or platelet counts. ...

    Topic section last updated 04/06/2018 - 12:30pm.

  4. Outcomes and healthcare utilization in children and young adults with aplastic anemia: A multiinstitutional analysis

    ... interval [CI] 0.6-2.58, P = 0.567), while every platelet transfusion was associated with higher mortality (OR 1.37, 95% CI ...

    Research Article last updated 07/18/2017 - 10:32am.

  5. A Biomarker-Directed Phase 2 Trial of SY-1425, a Selective Retinoic Acid Receptor Alpha Agonist, in Adult Patients with Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)

    ... and approved by the Sponsor prior to enrollment. Transfusion dependent lower-risk MDS without the del 5q abnormality, in ... x 10^9/L. Patients known to be refractory to platelet or packed red cell transfusions per Institutional Guidelines, or a ...

    Clinical Trial last updated 04/23/2018 - 1:35pm.

  6. Eltrombopag versus placebo for low-risk myelodysplastic syndromes with thrombocytopenia (EQoL-MDS): phase 1 results of a single-blind, randomised, controlled, phase 2 superiority trial.

    ... and severe thrombocytopenia. Patients with a stable platelet count of lower than 30 × 109 platelets per L, aged at least ... need for early trial termination. Duration of platelet transfusion independence, duration of response, overall survival, ...

    Research Article last updated 02/21/2017 - 9:49am.

  7. Efficacy, safety, and pharmacokinetics of subcutaneous azacitidine in Taiwanese patients with higher-risk myelodysplastic syndromes

    ... hematologic improvement, 12 of 32 patients attained RBC transfusion independence and 7 of 18 attained platelet transfusion independence. Most common grade 3-4 treatment-emergent ...

    Research Article last updated 02/03/2017 - 10:05am.

  8. Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes.

    ... this approach. Patients may require frequent blood and platelet transfusion support which is expensive and inconvenient. Life-threatening ...

    Research Article last updated 06/20/2013 - 10:13am.

  9. Alternative Donor Transplantation with High-Dose Post-Transplantation Cyclophosphamide for Refractory Severe Aplastic Anemia

    ... was 25 (range, 2 to 58) days, and to last platelet transfusion to keep platelets counts over 50 × 103/mm3 was 27.5 ...

    Research Article last updated 01/24/2017 - 10:04am.

  10. Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan

    ... change in hemoglobin (Hb) level, the withdrawal of transfusion and corticosteroids, the change of renal function, and overall ... were observed, especially in patients with platelet count ≥150 × 109/L. Approximately 97 % of patients showed ...

    Research Article last updated 11/02/2016 - 10:39am.