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  1. Self-injected PNH therapy on the horizon

    ... Across four patient groups, ACH-4471 achieved peak plasma concentrations between one and 2.5 hours after oral dosing. Up to ...

    Article last updated 07/07/2016 - 9:40am.

  2. When is iron overload deleterious, and when and how should iron chelation therapy be administered in myelodysplastic syndromes?

    ... transferrin -bound iron (NTBI), including labile plasma iron (LPI) and intracellular labile iron pools, which increase the ...

    Research Article last updated 03/06/2014 - 11:39am.

  3. Efficacy and safety of deferasirox in myelodysplastic syndromes

    ... naïve and pre-treated patients and to reduce labile plasma iron, independently from the efficacy on iron overload . ...

    Research Article last updated 03/05/2013 - 9:15am.

  4. Cytokine signature profiles in acquired aplastic anemia and myelodysplastic syndromes.

    ... about their circulating cytokine patterns. We compared plasma soluble cytokines in 33 aplastic anemia, 57 myelodysplasia ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Prospective assessment of effects on iron-overload parameters of deferasirox therapy in patients with myelodysplastic syndromes.

    ... on liver iron concentration (LIC), labile plasma iron (LPI) and pharmacokinetics (PK) along with serum ferritin ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Paroxysmal nocturnal hemoglobinuria from bench to bedside

    ... of all proteins that utilize GPI to attach to the plasma membrane. Two GPI-anchor proteins, CD55 and CD59, are complement ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Loss of expression of neutrophil proteinase-3: a contributory factor in thrombotic risk in paroxysmal nocturnal hemoglobinuria.

    ... proteinase 3 was associated with a decrease in plasma proteinase 3 levels, clone size and history of ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

    ... half-life of >5 days but may potentially affect the plasma levels of C3. Despite faster elimination kinetics, saturating ...

    Research Article last updated 03/06/2014 - 11:17am.

  9. Myelodysplastic Syndromes (MDS)

    ... Blood consists of blood cells floating in plasma . Plasma is mostly made of water. It also includes salts, proteins, hormones, ...

    Page last updated 02/27/2017 - 7:36am.

  10. Aplastic Anemia

    ... Blood consists of blood cells floating in plasma . Plasma is mostly made of water. It also includes salts, proteins, hormones, ...

    Page last updated 02/27/2017 - 7:34am.