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  1. Myelodysplastic syndromes: What do hospitalists need to know?

    ... Myelodysplastic syndromes (MDS) represent a blood disorder characterized by ineffective production of cells leading to low ... kidney function, bleeding, inflammation, and review of a peripheral blood smear.   Ultimately, the diagnosis of MDS requires a ...

    Research Review last updated 05/02/2016 - 9:21am.

  2. RIC Transplant Using Haplo Donors

    ... -mismatched first-degree relatives utilizing PBSC as the stem cell source. The primary objective of the study is to estimate the ... requiring transfusion not responding to therapy; peripheral or BM blast count of <10%; CMML Acute lymphocytic ... Day 4. Other Name: Cytoxan Procedure: peripheral blood stem cell transplant Other Name: HSCT ...

    Clinical Trial last updated 04/29/2016 - 10:52am.

  3. Intra-Osseous Co-Transplant of UCB and hMSC

    ... trial studies intra-osseous donor umbilical cord blood and mesenchymal stromal cell co-transplant in treating patients with ... blasts in the marrow and/or ≤ 5% blasts in the peripheral blood Acute lymphoblastic leukemia (ALL) ...

    Clinical Trial last updated 05/02/2016 - 11:15am.

  4. Microtransplantation to Treat Refractory or Relapsed Hematologic Malignancies in Younger Patients

    ... by an infusion of their donor's bone marrow or blood stem cells . The high-dose chemotherapy drugs and radiation are ... The chemotherapy is followed by an infusion of their donor's peripheral blood stem cells. The objective of the microtransplant is to ...

    Clinical Trial last updated 05/09/2016 - 3:01pm.

  5. Randomized Trial of Lenalidomide, Bortezomib, Dexamethasone vs High-Dose Treatment With SCT in MM Patients up to Age 65 (DFCI 10-106)

    ... syndrome (another type of cancer affecting the blood). Dexamethasone is commonly used, either alone, or in combination with ... and cyclophosphamide , the drugs used during stem cell collection and transplant, are also approved by the FDA. Melphalan is ... to comply with an anti-thrombotic treatment regimen Peripheral neuropathy >/= Grade 2 ...

    Clinical Trial last updated 05/23/2016 - 3:45pm.

  6. TBI Dose De-escalation for Fanconi Anemia

    ... . 4) If the subject is receiving bone marrow or "peripheral" stem cells (cells collected from the donor's arm via a cell ... stem cells. If the subject is receiving an umbilical cord blood, the lymphocytes will not be removed because the risk of GVHD is not as ...

    Clinical Trial last updated 04/28/2016 - 9:06am.

  7. HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy (RAFA)

    ... filgrastim neupogen Biological: Peripheral blood stem cell The source of stem cells for all patients will be ...

    Clinical Trial last updated 05/09/2016 - 3:19pm.

  8. PRO#1278: Fludarabine and Busulfan vs. Fludarabine, Busulfan and Total Body Irradiation (FLUBUTBI)

    ... to donate bone marrow using standard techniques or peripheral blood HSC by leukapheresis Have adequate veins for apheresis or agree to ...

    Clinical Trial last updated 04/29/2016 - 3:09pm.

  9. Biparental HLA Haplotype Disparate T-cell Depleted Transplants for Patients Lacking an HLACompatible Donor

    ... of a specific kind of transplant. In this transplant, blood from two donors will be used. Each donor will share one half of your HLA ... by institutional policies Donor must have adequate peripheral venous catheter access for leukapheresis or must agree to placement ...

    Clinical Trial last updated 04/29/2016 - 1:59pm.

  10. Allo vs Hypomethylating/Best Supportive Care in MDS (BMT CTN 1102)

    ... Allogeneic Hematopoietic Cell Transplant Bone marrow or peripheral blood stem cell transplant. The specific transplant treatment regimen will be ...

    Clinical Trial last updated 04/28/2016 - 10:50am.