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  1. Immunomodulating drugs in myelodysplastic syndromes

    ... mechanisms that appear to play an important role in the pathophysiology of at least part of the lower-risk myelodysplastic syndrome ...

    Research Article last updated 01/09/2012 - 2:00pm.

  2. Aplastic anemia: immunosuppressive therapy in 2010

    ... by an empty bone marrow; an immune-mediated pathophysiology has been demonstrated by experimental works as well as by ...

    Research Article last updated 11/08/2011 - 7:59am.

  3. Epigenetic regulation in myelodysplastic syndromes: implications for therapy.

    ... that targeting epigenetic mechanisms improves MDS/AML pathophysiology . AREAS COVERED: This review provides an understanding of ...

    Research Article last updated 10/11/2011 - 5:58pm.

  4. A closer look at paroxysmal nocturnal hemoglobinuria

    ... This review summarizes current knowledge of the pathophysiology , diagnostic modalities, clinical implications, and ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders

    ... diseases with a proved or suspected complement-mediated pathophysiology have been considered as candidate for a clinical complement ...

    Research Article last updated 10/02/2012 - 10:00am.

  6. The helix-loop-helix transcription factor TWIST is dysregulated in myelodysplastic syndromes.

    ... data suggest role for dysregulation of TWIST in the pathophysiology of MDS. Conceivably, TWIST or components in the signaling ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Immunological derangement in hypocellular myelodysplastic syndromes

    ... are pivotal not only for a better understanding of MDS pathophysiology , but also for their immediate clinical implications, ...

    Research Article last updated 05/22/2014 - 9:53am.

  8. Anti-Complement Treatment in Paroxysmal Nocturnal Hemoglobinuria: Where we Stand and Where we are Going

    ... Here we review PNH and its complement-mediated pathophysiology , summarizing available data on anti-complement treatment; ...

    Research Article last updated 05/22/2014 - 8:24am.

  9. Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.

    ... together, these findings provide new insight into MDS pathophysiology . IFNgamma and TNFalpha activate NF-kappaB that in turn ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. Decreased plasma cytokines associate with low platelet counts in aplastic anemia and immune thrombocytopenic purpura

    ... allowed testable inferences concerning physiology and pathophysiology in quantitative platelet disorders. © 2012 International ...

    Research Article last updated 07/30/2012 - 1:53pm.