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  1. The molecular basis and clinical significance of genetic mutations identified in myelodysplastic syndromes

    ... and a predisposition to acute myeloid leukemia. The pathophysiology of MDS has not been well illustrated. Nevertheless, ... all novel key mutations in MDS and their significance in pathophysiology and clinical practice. ...

    Research Article last updated 01/20/2015 - 1:08pm.

  2. Anemia as the Main Manifestation of Myelodysplastic Syndromes

    ... and symptoms of anemia in MDS, as well as its peculiar pathophysiology , are discussed. Erythopoietic stimulating agents (ESAs) ... del5q constitute a unique model of anemia whose complex pathophysiology has been clarified at least partially, defining its link to ...

    Research Article last updated 12/02/2015 - 8:45am.

  3. Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

    ... in patients has improved our understanding of the pathophysiology of this disease. However, the specific molecular mechanisms ...

    Research Article last updated 04/29/2016 - 11:35am.

  4. Molecular Testing in Myelodysplastic Syndromes for the Practicing Oncologist: Will the Progress Fulfill the Promise?

    ... recurrent mutations that play a vital role in the pathophysiology of MDS and the impact of these genetic changes on disease ...

    Research Article last updated 09/28/2015 - 9:48am.

  5. Genetics factors associated with myelodysplastic syndromes

    ... recurrent mutations, leading to new insights into the pathophysiology of MDS. The recent recognition that genes involved in the ...

    Research Article last updated 06/03/2015 - 11:30am.

  6. Non-t(6;9) and Non-Inv(3) Balanced Chromosomal Rearrangements Are Associated With Poor Survival Outcomes in Myelodysplastic Syndromes

    ... collected. Direct sequencing for genes relevant in MDS pathophysiology was performed on patients with BCR. Categorical data were ...

    Research Article last updated 06/03/2015 - 8:44am.

  7. Myelodysplastic syndromes

    ... the syndromes are most common in elderly people. The pathophysiology involves cytogenetic changes with or without gene ...

    Research Article last updated 04/16/2014 - 12:04pm.

  8. Iron overload and chelation therapy in myelodysplastic syndromes

    ... in depth analysis of iron overload in MDS patients; its pathophysiology , effect on survival, associated risks and diagnostic ...

    Research Article last updated 03/12/2014 - 10:20am.

  9. Stem cell origin of myelodysplastic syndromes

    ... of multipotent, immature hematopoietic cells in the pathophysiology of this disease. Recent studies using murine models of MDS ...

    Research Article last updated 01/08/2014 - 9:05am.

  10. Paroxysmal nocturnal hemoglobinuria and the age of therapeutic complement inhibition

    ... to nitric oxide depletion that mediates the pathophysiology of some of the common clinical signs of PNH. Clinical ...

    Research Article last updated 11/05/2013 - 12:37pm.