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  1. Clinical effect of point mutations in myelodysplastic syndromes

    ... myelodysplastic syndromes. We then examined whether the mutation status for each gene was associated with clinical variables, ... A total of 51% of all patients had at least one point mutation, including 52% of the patients with normal cytogenetics . ...

    Research Article last updated 10/11/2011 - 5:58pm.

  2. Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

    ... older persons, detection of an MDS-associated somatic mutation in a cytopenic patient without other evidence of MDS may cause ...

    Research Article last updated 06/03/2015 - 1:38pm.

  3. The molecular pathogenesis of the myelodysplastic syndromes

    ... a pathway not previously known as a target for mutation , in the MDS pathogenesis. Several regulators of signal ...

    Research Article last updated 03/04/2015 - 1:52pm.

  4. Non-t(6;9) and Non-Inv(3) Balanced Chromosomal Rearrangements Are Associated With Poor Survival Outcomes in Myelodysplastic Syndromes

    ... which might be influenced by the presence of SRSF2 mutation . Bone Marrow ...

    Research Article last updated 06/03/2015 - 8:44am.

  5. Aplastic Anemia & MDS International Foundation: Bone marrow failure disease scientific symposium 2012

    ... from patients with critically short telomeres and/or mutation in telomerase genes. The possibility of modulating telomere ...

    Research Article last updated 01/23/2015 - 3:36pm.

  6. Minimal morphological criteria for defining bone marrow dysplasia: a basis for clinical implementation of WHO classification of myelodysplastic syndromes

    ... mutations, and between severe granulocytic dysplasia and mutation of ASXL1, RUNX1, TP53 and SRSF2 genes. In myeloid neoplasms with ...

    Research Article last updated 07/07/2014 - 9:47am.

  7. Somatic mutations and epigenetic abnormalities in myelodysplastic syndromes

    ... prognosis, while some gene mutations (mainly TET2 mutation ), may be associated to better response to hypomethylating agents. ...

    Research Article last updated 03/06/2014 - 11:45am.

  8. Prognostic value of telomere attrition in patients with aplastic anemia.

    ... from patients with critically short telomeres and/or mutation in telomerase genes. The possibility of modulating telomere ...

    Research Article last updated 06/20/2013 - 10:25am.

  9. Emerging roles of the spliceosomal machinery in myelodysplastic syndromes and other hematological disorders

    ... to intense investigation. For SF3b1, a gain of function mutation may offer the promise of new targeted therapies for diseases that ...

    Research Article last updated 07/31/2012 - 2:06pm.

  10. Clonal diversity of recurrently mutated genes in myelodysplastic syndromes

    ... (VAFs) for founding clone mutations. At least one mutation or cytogenetic abnormality was detected in 83% of the 150 MDS ...

    Research Article last updated 03/05/2013 - 8:30am.