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  1. Major news in BMT with half-match donors

    ... had specific mutations in his cancer cells. We found a mutation called IDH 2, which causes the body to produce an abnormal protein that promotes excessive cell growth. If you can target that mutation and stop the abnormal protein from being produced, then cells start ...

    Article last updated 06/14/2016 - 3:02pm.

  2. Top expert calls future MDS/AML care “promising”

    ... about this. Let’s say you have a very particular mutation that happens in 1% or 2% of the patients with this disease. ... “OK, this is exactly what the patient has, this is the mutation that the patient has, etcetera.” Then, maybe you work with the ...

    Article last updated 11/02/2016 - 11:28am.

  3. Paroxysmal nocturnal hemoglobinuria and the age of therapeutic complement inhibition

    ... disease of hematopoietic stem cells due to a mutation in the PIG-A gene leading to a deficiency of GPI-anchored ...

    Research Article last updated 11/05/2013 - 12:37pm.

  4. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... all ages. PNH is caused by the acquisition of a somatic mutation of the gene phosphatidylinositol glycan anchor (PIG-A) in a ... cell (HSC), with clonal expansion of the mutated HSC. The mutation causes a deficiency in the synthesis of glycosylphosphatidylinositol ...

    Research Article last updated 05/14/2013 - 3:28pm.

  5. Personalized medicine for MDS

    ... example, a younger patient with a negative prognostic mutation may be considered for a more intensive treatment, such as ... About 20% of patients with del (5q) have a concurrent TP53 mutation which suggests more aggressive disease and should be treated ...

    Research Review last updated 05/02/2016 - 9:44am.

  6. Investigation of 305 patients with myelodysplastic syndromes and 20q deletion for associated cytogenetic and molecular genetic lesions and their prognostic impact

    ... by fluorescence in situ hybridization , molecular mutation screening, and array comparative genomic hybridization (aCGH). By ...

    Research Article last updated 01/08/2014 - 8:30am.

  7. Advances in the molecular pathology of MDS

    ... clinical practice. The frequent finding of more than one mutation in patients confirms that MDS are a group of heterogeneous ...

    Research Review last updated 05/02/2016 - 9:44am.

  8. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... marrow failure . PNH is due to a somatic, acquired mutation in the X-linked phosphatidylinositol glycan class A (PIG-A) gene, ...

    Research Article last updated 03/05/2013 - 9:38am.

  9. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... marrow failure . PNH is due to a somatic, acquired mutation in the X-linked phosphatidylinositol glycan class A (PIG-A) gene, ...

    Research Article last updated 10/02/2012 - 9:57am.

  10. Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry.

    ... stem cell disorder characterized by a somatic mutation in the PIGA gene, leading to a deficiency of proteins linked to ...

    Research Article last updated 10/11/2011 - 5:58pm.