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  1. Prognostic significance of SETBP1 mutations in myelodysplastic syndromes, chronic myelomonocytic leukemia, and chronic neutrophilic leukemia: A meta-analysis

    ... to calculate the prognostic significance of SETBP1 mutation in patients. RESULTS: A total of 12 studies with 2321 ... CONCLUSIONS: Current evidence shows that SETBP1 mutation is associated with a poor prognosis in patients with MDS and CMML, but ...

    Research Article last updated 02/21/2017 - 10:33am.

  2. David Araten, MD

    ... cells. This clone has as its feature the presence of a mutation in a gene called PIG-A. Different patients have different types of ... PNH. We have recently found 4 patients with PNH who have a mutation in genes other than PIG-A--  the JAK2 and the TET2 genes. Three out ...

    Grant Recipient last updated 11/30/2016 - 10:51am.

  3. Genetics and Epigenetics of Myelodysplastic Syndromes and Response to Drug Therapy: New Insights

    ... About 90% of patients harbor at least one somatic mutation . This review aimed to assess the potential of molecular ... In addition, patients with del5q subtype harboring TP53 mutation do not show a good response to lenalidomide therapy. In ...

    Research Article last updated 02/01/2017 - 8:15am.

  4. TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes

    ... at multiple time points to evaluate patterns of mutation clearance in 54 patients. An extension cohort included 32 ... had favorable clinical responses and robust (but incomplete) mutation clearance after receiving serial 10-day courses of decitabine. ...

    Research Article last updated 01/26/2017 - 10:07am.

  5. The role of p53 in myelodysplastic syndromes and acute myeloid leukemia: molecular aspects and clinical implications

    ... the size of the TP53 mutant clone as measured by mutation allele burden is directly linked to overall survival (OS) ...

    Research Article last updated 01/26/2017 - 10:06am.

  6. Phase 1/2 Study of AG-221 in Subjects With Advanced Hematologic Malignancies With an IDH2 Mutation

    ... advanced hematologic malignancies that harbor an IDH2 mutation . The study includes a dose escalation phase to determine the ...

    Clinical Trial last updated 05/03/2016 - 11:40am.

  7. Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation

    ... in advanced hematologic malignancies that harbor an IDH1 mutation . The first portion of the study is a dose escalation phase where ...

    Clinical Trial last updated 05/03/2016 - 11:37am.

  8. New study hails test to weigh SCT for MDS

    ... patient’s MDS was whether their blood cells carried a mutation in the gene TP53. These patients tended to survive for a shorter ... relapse more quickly, than patients whose cells lacked that mutation. This was true whether patients received standard “conditioning” ...

    Article last updated 02/09/2017 - 9:03am.

  9. Pathogenesis of paroxysmal nocturnal hemoglobinuria

    ... (PNH) is an acquired GPI deficiency caused by somatic mutation of the PIGA gene in one or several hematopoietic stem cells . Recently, PNH caused by somatic mutation of one allele of the PIGT gene in combination with a germline mutation ...

    Research Article last updated 11/02/2016 - 2:52pm.

  10. Implications of molecular genetic diversity in myelodysplastic syndromes

    ... syndromes (MDS) have remarkably diverse somatic mutation patterns that can be challenging to interpret clinically. Yet, ...

    Research Article last updated 12/09/2016 - 2:54pm.