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  1. Personalized Natural Killer (NK) Cell Therapy in Cord Blood Transplantation (CBT)

    ... abn(17p), MLL gene re-arrangement and t (6;9)47, flt3 mutation positive and/or evidence of minimal residual disease by flow ...

    Clinical Trial last updated 06/06/2016 - 10:28am.

  2. Cord Blood Fucosylation to Enhance Homing and Engraftment in Patients With Hematologic Malignancies

    ... or high-risk cytogenetics , flt3 mutation positive and/or evidence of minimal residual disease by flow ...

    Clinical Trial last updated 06/06/2016 - 12:58pm.

  3. Azacytidine Prior to in Vivo T-cell Depleted Allo Stem Cell Transplant for Patients With Myeloid Malignancies in CR

    ... abnormalities); or Acute myeloid leukemia with Flt-3 mutation in complete hematologic remission; or Acute myeloid leukemia, ...

    Clinical Trial last updated 05/02/2016 - 11:10am.

  4. Immune System Suppression and Bone Marrow Failure

    ... DNMT3A  and  ASXL1 and another had a RUNX1 mutation . Telomeres were very short in all of the patients with monosomy 7. ...

    Research Review last updated 05/02/2016 - 9:15am.

  5. Scientific Symposium Co-Chair Richard Stone, MD Discusses Progress and New Directions in Bone Marrow Failure Disease Research

    ... stem cell development, or a telomeropathy caused by mutation in genes encoding for members of the telomere complex. A ...

    Interview last updated 04/29/2014 - 12:01pm.

  6. Hideki Makishima, MD, PhD

    ... 1. Shen, W. et al. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria . J ...

    Bio last updated 03/11/2016 - 1:41pm.

  7. Overlap Syndromes: When PNH Appears with Aplastic Anemia or MDS

    ... platelet count, especially if they have the JAK2 mutation . Does PNH appear concurrently with the other diseases or does ...

    Interview last updated 05/14/2015 - 1:53pm.

  8. Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET)

    ... count <1.5 x 10 to 9/L     JAK2 exon 12 mutation : PV that lacks the JAK2V617F mutation but is characterized by the exon 12 mutation.     Meets criteria ...

    Clinical Trial last updated 05/02/2016 - 2:31pm.

  9. Pegylated Interferon Alfa-2a Salvage Therapy in High Risk Polycythemia Vera (PV) or Essential Thrombocythemia (ET)

    ... investigational agent. Presence of JAK2 exon 12 mutation Patients should not meet criteria for post PV or post ET-MF ...

    Clinical Trial last updated 04/29/2016 - 9:59am.

  10. From Bench to Bedside: Why Research is Important

    ... found on our website include: Telomere gene mutation may be found in patients who seem to have a primary immune defect, ...

    Page last updated 03/19/2016 - 12:22pm.