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  1. Zhe Yang, PhD

    ... in MDS. The exciting new discovery of frequent Tet2 mutation in a wide range of myeloid malignancies including ...

    Grant Recipient last updated 12/06/2013 - 4:25pm.

  2. Mridul Mukherji, DPhil

    ... (MDS). Results from recent studies have established that mutation in the TET2 tumor suppressor gene is one of the fundamental causes ...

    Grant Recipient last updated 10/01/2012 - 10:46am.

  3. Hideki Makishima, MD, PhD

    ... 1. Shen, W. et al. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria . J ...

    Bio last updated 03/11/2016 - 1:41pm.

  4. Scientific Symposium Co-Chair Richard Stone, MD Discusses Progress and New Directions in Bone Marrow Failure Disease Research

    ... stem cell development, or a telomeropathy caused by mutation in genes encoding for members of the telomere complex. A ...

    Interview last updated 04/29/2014 - 12:01pm.

  5. Overlap Syndromes: When PNH Appears with Aplastic Anemia or MDS

    ... platelet count, especially if they have the JAK2 mutation . Does PNH appear concurrently with the other diseases or does ...

    Interview last updated 05/14/2015 - 1:53pm.

  6. Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET)

    ... count <1.5 x 10 to 9/L     JAK2 exon 12 mutation : PV that lacks the JAK2V617F mutation but is characterized by the exon 12 mutation.     Meets criteria ...

    Clinical Trial last updated 05/02/2016 - 2:31pm.

  7. Pegylated Interferon Alfa-2a Salvage Therapy in High Risk Polycythemia Vera (PV) or Essential Thrombocythemia (ET)

    ... investigational agent. Presence of JAK2 exon 12 mutation Patients should not meet criteria for post PV or post ET-MF ...

    Clinical Trial last updated 04/29/2016 - 9:59am.

  8. From Bench to Bedside: Why Research is Important

    ... found on our website include: Telomere gene mutation may be found in patients who seem to have a primary immune defect, ...

    Page last updated 03/19/2016 - 12:22pm.

  9. Dose-Escalation Study of FT-2102 as a Single Agent and in Combination With Azacitidine in Patients With AML or MDS With an IDH1 Mutation

    ...

    Clinical Trial last updated 04/29/2016 - 1:06pm.

  10. Midostaurin and Azacitidine in Treating Elderly Patients With Acute Myelogenous Leukemia

    ... Other: flow cytometry Correlative study Other: mutation analysis Correlative study Other: pharmacological study ...

    Clinical Trial last updated 06/03/2016 - 2:24pm.