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  1. Donor Lymphocyte Infusion (DLI) of T-cells Genetically Modified With iCasp9 Suicide Gene

    ... intermediate or high cytogenetic risk factors or flt3 mutation . Patients with relapsed disease. Patients with primary induction ...

    Clinical Trial last updated 06/06/2016 - 12:41pm.

  2. Personalized Natural Killer (NK) Cell Therapy in Cord Blood Transplantation (CBT)

    ... abn(17p), MLL gene re-arrangement and t (6;9)47, flt3 mutation positive and/or evidence of minimal residual disease by flow ...

    Clinical Trial last updated 06/06/2016 - 10:28am.

  3. Daria Babushok, MD, PhD

    ... progeny of a single cell that initially acquired a given mutation . This phenomenon, where a large fraction of blood cells originate ...

    Bio last updated 03/11/2016 - 1:41pm.

  4. Detection of Recurrent Mutations by Pooled Targeted Next-Generation Sequencing in MDS Patients Prior to Treatment with Hypomethylating Agents or Stem Cell Transplantation

    ... (14%) genes.   In Cohort 2, 37% of patients had a mutation in a splicing factor gene ( SF3B1 , U2AF1 , SRSF2 , or ... of patients in Cohort 2 than Cohort 1 had a genetic mutation associated with a poor prognosis (especially TP53 ). Also, fewer ...

    Research Review last updated 05/02/2016 - 9:26am.

  5. Cord Blood Fucosylation to Enhance Homing and Engraftment in Patients With Hematologic Malignancies

    ... or high-risk cytogenetics , flt3 mutation positive and/or evidence of minimal residual disease by flow ...

    Clinical Trial last updated 06/06/2016 - 12:58pm.

  6. Eric Padron, M.D.

    ... Other work Dr. Padron is pursuing involves the SRSF2 mutation that can occur in MDS and may be related to progression to other ...

    Bio last updated 03/11/2016 - 1:41pm.

  7. Rosannah Cameron, PhD.

    ... blood-forming stem cells, we study zebrafish that have a mutation in a spliceosomal gene commonly mutated in MDS (sf3b1). The aim of ...

    Bio last updated 03/11/2016 - 1:41pm.

  8. Pathogenesis of MDS: An overview of molecular and non-molecular aspects of the disease

    ... that 78% of MDS patients carry at least one somatic mutation .  Knowledge of these mutations may help in diagnosing patients as ...

    Research Review last updated 05/02/2016 - 9:14am.

  9. Azacytidine Prior to in Vivo T-cell Depleted Allo Stem Cell Transplant for Patients With Myeloid Malignancies in CR

    ... abnormalities); or Acute myeloid leukemia with Flt-3 mutation in complete hematologic remission; or Acute myeloid leukemia, ...

    Clinical Trial last updated 05/02/2016 - 11:10am.

  10. Immune System Suppression and Bone Marrow Failure

    ... DNMT3A  and  ASXL1 and another had a RUNX1 mutation . Telomeres were very short in all of the patients with monosomy 7. ...

    Research Review last updated 05/02/2016 - 9:15am.