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  1. Study of Orally Administered AG-881 in Patients With Advanced Hematologic Malignancies With an IDH1 and/or IDH2 Mutation

    ... hematologic malignancies that harbor an IDH1 and/or IDH2 mutation Status:  ...

    Clinical Trial last updated 04/28/2016 - 10:59am.

  2. PNH: Secondary Mutations and Thrombosis

    ... a brief overview of the common PIG-A gene mutation that occurs in PNH patients and how different patients have ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  3. Clinical mutations associated with MDS and their importance for disease outcome

    ... new drugs based on what we know about a specific mutation in a specific gene. This study analyzed samples from 738 ...   this was 49 months for patients with one oncogenic mutation, 42 for patients with two oncogenic mutations, and 27, 18 and four ...

    Research Review last updated 05/02/2016 - 9:21am.

  4. Myelofibrosis (MF)

    ... to myelofibrosis over time The presence of the JAK2 mutation Exposure to certain industrial chemicals, such as toluene and ...

    Topic section last updated 07/07/2016 - 3:16pm.

  5. Causes

    ... PNH happens because of a change ( mutation ) in the PIG-A gene of a single stem cell in your bone ... people have a small number of stem cells with a PIG-A mutation. But in people with PNH, these stem cells grow fast and make lots of ...

    Topic section last updated 03/29/2016 - 6:15pm.

  6. Hideki Makishima, MD, PhD

    ... PNH is a disease in which a mutation in the gene called PIG-A is acquired in the stem cells ... While previous discover of the PIG-A gene mutation has helped to explain the symptoms in the disease, it remains unclear ...

    Grant Recipient last updated 07/07/2014 - 11:46am.

  7. Phase I/II MAHCT w/ TCell Depleted Graft w/ Simultaneous Infusion Conventional and Regulatory T Cell

    ... t(3;3) t(6;9) t(9;22) Normal karyotype with FLT3-ITD mutation Chronic myelogenous leukemia (accelerated, blast or ...

    Clinical Trial last updated 05/09/2016 - 3:58pm.

  8. Intra-Osseous Co-Transplant of UCB and hMSC

    ... markers (e.g. fms-related tyrosine kinase 3 [Flt 3] mutation , 11q23, del 5, del 7, complex cytogenetics) Second complete ...

    Clinical Trial last updated 05/02/2016 - 11:15am.

  9. Dr. Vivienne Rebel reports on a study of the relationship between gene mutations and overall survival after stem cell transplant

    ... survival after transplantation for patients with this mutation was only 4.6 months and none lived much beyond 4 years.  Thus, it ... has minimal, if any, benefits for MDS patients with a TP53 mutation.  The authors conclude that if a blood-stem cell transplantation is ...

    Research Review last updated 05/02/2016 - 9:16am.

  10. Identification of genetic abnormalities in MDS patients that may lead to a better diagnosis and treatment strategy of MDS patients

    ... (nearly twice as high) in the group of patients with a mutation in the TET2 gene in their blood cells compared to the group who did not have this mutation.  Mutations that can predict therapeutic outcome are of importance ...

    Research Review last updated 05/02/2016 - 9:23am.