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  1. Dynamics of DNMT3A mutation and prognostic relevance in patients with primary myelodysplastic syndrome

    ... Article Link:  Dynamics of DNMT3A mutation and prognostic relevance in patients with primary myelodysplastic ... Background DNMT3A  gene mutation has been associated with poor prognosis in acute myeloid leukemia, ...

    Article last updated 04/03/2018 - 1:32pm.

  2. SF3B1 mutations in patients with myelodysplastic syndromes: the mutation is stable during disease evolution

    ... The SF3B1 mutation can be detected in patients with myelodysplastic syndrome (MDS), but the report regarding the association of this mutation with other genetic alterations and its stability during disease ...

    Research Article last updated 04/23/2014 - 11:18am.

  3. TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases

    ... BACKGROUND: TP53 mutation is more prevalent in therapy-related myeloid neoplasms (t-MN) ... t-MN, in which 40 patients (37%) had TP53 mutations. The mutation frequency was similar between t-MDS and t-AML; but significantly ...

    Research Article last updated 06/03/2015 - 1:04pm.

  4. A Study of E6201 for the Treatment of Advanced Hematologic Malignancies With FLT3 Mutation (AML)

    ... advanced hematologic malignancies with documented FLT3 mutation . The Phase1 portion of the study will be a safety run-in to ... with relapsed or refractory AML and confirmed FLT3 mutation without prior exposure to a FLT3 inhibitor while Cohort 2 will enroll ...

    Clinical Trial last updated 05/09/2016 - 4:09pm.

  5. Distinct mutation profile and prognostic relevance in patients with hypoplastic myelodysplastic syndromes (h-MDS)

    Journal Title:  Oncotarget Primary Author:  Yao CY Author(s):  Yao CY, Hou HA...

    Research Article last updated 09/19/2016 - 11:07am.

  6. The phenotype of a germline mutation in PIGA: the gene somatically mutated in paroxysmal nocturnal hemoglobinuria

    ... sequencing screen identified a single nonsense PIGA mutation , c.1234C>T, which predicts p.Arg412(∗). This variant segregated ... The genetic data show that the c.1234C>T (p.Arg412(∗)) mutation is present in an affected child, is linked to the affected chromosome ...

    Research Article last updated 07/30/2012 - 2:24pm.

  7. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria

    ... within the PIGA-mutant population, or prior to PIGA mutation . Together, our data indicate that in addition to PIGA mutations, ...

    Research Article last updated 10/02/2014 - 8:24am.

  8. Impact of TP53 mutation variant allele frequency on phenotype and outcomes in myelodysplastic syndromes

    Journal Title:  Leukemia Primary Author:  Sallman DA Author(s):  Sallman DA, ...

    Research Article last updated 12/08/2015 - 1:04pm.

  9. The relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation in myelodysplastic syndromes

    Journal Title:  Blood Cancer J Primary Author:  McGraw KL Original Publication Date:  ...

    Research Article last updated 04/08/2015 - 11:21am.

  10. Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes

    Journal Title:  Nat Commun. Primary Author:  Gerstung M Author(s):  Gerstung ...

    Research Article last updated 03/02/2015 - 1:43pm.