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  1. SF3B1 mutations in patients with myelodysplastic syndromes: the mutation is stable during disease evolution

    ... The SF3B1 mutation can be detected in patients with myelodysplastic syndrome (MDS), but the report regarding the association of this mutation with other genetic alterations and its stability during disease ...

    Research Article last updated 04/23/2014 - 11:18am.

  2. TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases

    ... BACKGROUND: TP53 mutation is more prevalent in therapy-related myeloid neoplasms (t-MN) ... t-MN, in which 40 patients (37%) had TP53 mutations. The mutation frequency was similar between t-MDS and t-AML; but significantly ...

    Research Article last updated 06/03/2015 - 1:04pm.

  3. Targeted next-generation sequencing in myelodysplastic syndromes and prognostic interaction between mutations and IPSS-R

    ... 17% intermediate, 38% low and 16% very low. At least one mutation /variant was detected in 147 (82%) patients; 23% harbored three or ... 41% and 20% of patients harbored at least one adverse mutation/variant for overall and leukemia-free survival, respectively. Number ...

    Research Article last updated 09/18/2017 - 11:05am.

  4. FDA approves new drug for relapsed or refractory AML

    ... leukemia with an isocitrate dehydrogenase-2 (IDH2) mutation as detected by an FDA-approved test. This is the first FDA ... for relapsed or refractory AML specifically with an IDH2 mutation. The FDA concurrently approved a companion diagnostic, the RealTime ...

    Article last updated 08/30/2017 - 8:30am.

  5. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... thrombosis . The etiology of PNH is a somatic mutation in the phosphatidylinositol glycan class A gene ( PIG-A ) on the ...

    Research Article last updated 07/27/2017 - 2:06pm.

  6. Making Progress for Myelodysplastic Syndromes

    ... sideroblasts or a certain gene splicing mutations, SF3B1 mutation . Other studies are testing drugs that can target the IDH2 mutation. They have been tested in leukemias and in subsets of patients with ...

    Article last updated 07/26/2017 - 10:25am.

  7. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... thrombosis . The etiology of PNH is a somatic mutation in the phosphatidylinositol glycan class A gene (PIG-A) on the X ...

    Research Article last updated 07/11/2017 - 10:43am.

  8. A Study of E6201 for the Treatment of Advanced Hematologic Malignancies With FLT3 Mutation (AML)

    ... advanced hematologic malignancies with documented FLT3 mutation . The Phase1 portion of the study will be a safety run-in to ... with relapsed or refractory AML and confirmed FLT3 mutation without prior exposure to a FLT3 inhibitor while Cohort 2 will enroll ...

    Clinical Trial last updated 05/09/2016 - 4:09pm.

  9. New Insight Into the Biology, Risk Stratification, and Targeted Treatment of Myelodysplastic Syndromes

    ... Although many MDS cases harbor more than one somatic mutation , in general, there is mutual exclusivity of mutated genes within a ...

    Research Article last updated 06/26/2017 - 9:16am.

  10. Distinct mutation profile and prognostic relevance in patients with hypoplastic myelodysplastic syndromes (h-MDS)

    Journal Title:  Oncotarget Primary Author:  Yao CY Author(s):  Yao CY, Hou HA...

    Research Article last updated 09/19/2016 - 11:07am.