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  1. Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia.

    ... higher in patients in the first quartile (24.5%; 95% CI, 8.7%-37.5%) than in quartiles 2 through 4 (8.4%; 95% CI, 3.2%-13.3%; P = .009), and evolution to monosomy 7 or complex cytogenetics was more common in the first ...

    Research Article last updated 10/11/2011 - 5:58pm.

  2. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... total nucleated cell (TNC) dose must be a minimum of 4.0 x10^7/kg recipient weight. For double cord transplants, each unit must have a ... syndrome (pre-MDS) or MDS on marrow examination (e.g. Monosomy 7 ). Presence of anti-donor HLA antibodies (positive ...

    Clinical Trial last updated 05/22/2017 - 11:00am.

  3. Clonal Evolution in Aplastic Anemia is Driven by Chromosomal Instability Rather than Mutations in Myeloid Malignancy Candidate Gene

    ... Society of Hematology (ASH) Annual Meeting, December 7-10 in New Orleans, Louisiana.The full abstract may be reviewed on the ASH ... with aplastic anemia. Aplastic anemia had progressed to monosomy 7 in 13 of these patients. Monosomy 7, a type of MDS, involves the ...

    Research Review last updated 05/02/2016 - 9:20am.

  4. The Challenging World of Cytopenias: Distinguishing Myelodysplastic Syndromes From Other Disorders of Marrow Failure.

    ... other bone marrow failure disorders, such as del (5q), monosomy 7 , inversion 3, del (Y), 20q, and trisomy 8 among others. The ...

    Research Review last updated 05/02/2016 - 9:18am.

  5. Immune System Suppression and Bone Marrow Failure

    ... examined patients whose aplastic anemia progressed to monosomy 7 (meaning that they had only one copy, instead of the usual two copies, of ...

    Research Review last updated 05/02/2016 - 9:15am.

  6. Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia

    ... will develop an abnormal karyotype in follow-up, with monosomy 7 being most common, which portends progression to myelodysplasia and ...

    Clinical Trial last updated 04/25/2016 - 2:47pm.

  7. Nonmyeloablative Haploidentical Transplant Followed by MLN9708

    ... Myelodysplastic Syndrome (treatment-related, monosomy 7 or complex cytogenetics, IPSS score of 1.5 or greater, Chronic ...

    Clinical Trial last updated 04/29/2016 - 1:05pm.

  8. Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

    ... (> 3 abnormalities); inv(3) or t(3;3); t(6;9); t(6;11); monosomy 7 ; trisomy 8, alone or with an abnormality other than t(8;21), t(9;11), ...

    Clinical Trial last updated 04/29/2016 - 1:00pm.

  9. Transplantation Update

    ... we consider complex,  high-risk cytogenetics ( monosomy 7 and others) which was the major cause of failure due to relapse in ...

    Interview last updated 05/14/2015 - 2:42pm.

  10. Pediatric MDS

    ... We have had a few families we have treated with familial monosomy 7 -related MDS, and that doesn’t occur on the adult side. Finally, some of ...

    Interview last updated 10/24/2012 - 1:31pm.