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  1. Prevalence, clinical characteristics and prognosis of GATA2-related myelodysplastic syndromes (MDS) in children and adolescents

    ... Germline GATA2 mutations accounted for 15% of advanced and 7% of all primary MDS cases, but were absent in children with MDS secondary to ... were older at diagnosis and more likely to present with monosomy 7 and advanced disease as compared to wildtype cases. For ...

    Research Article last updated 04/29/2016 - 10:24am.

  2. Very Short Telomeres of Peripheral Blood Leukocytes Precede Clinical Progression to Myelodysplasia with Monosomy 7 in Aplastic Anemia Patients

    ... Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia. The full abstracts may be viewed on the ASH Annual ...

    Research Review last updated 05/02/2016 - 9:24am.

  3. Outcome of children with severe acquired aplastic anemia treated with rabbit antithymocyte globulin and cyclosporine A

    ... after immunosuppressive therapy was 8.3% (95% CI: 0.001%-53.7%) at five years with both clonal evolutions in non -responders who acquired monosomy 7 karyotype. The overall survival at five years was 73.6% (95% ...

    Research Article last updated 06/19/2014 - 12:45pm.

  4. Horse antithymocyte globulin as salvage therapy after rabbit antithymocyte globulin for severe aplastic anemia

    ... of relapse, and in nonresponders 2 patients evolved to monosomy 7 . The overall survival for the cohort at 3 years was 68% (95% CI, ...

    Research Article last updated 02/04/2014 - 1:27pm.

  5. Pediatric myelodysplastic syndromes: they do exist!

    ... associated with hypocellular bone marrow and monosomy 7 . Refractory cytopenia is more typical than refractory anemia ...

    Research Article last updated 01/08/2014 - 9:02am.

  6. Hematopoietic stem cell transplantation in children and young adults with secondary myelodysplastic syndrome and acute myeloid leukemia following aplastic anemia

    ... At a median age of 13.1 years (range, 4.4 to 26.7 years), patients underwent HSCT with bone marrow (n = 6) or ... family donors (n = 2), or unrelated donors (n = 13). Monosomy 7 was detected in 13 patients. The preparative regimen consisted ...

    Research Article last updated 01/07/2014 - 12:37pm.

  7. Clonal evolution in aplastic anemia

    ... of diagnostic chromosomal abnormalities (mostly monosomy 7 ) is of great clinical importance. Newer whole-genome scanning ...

    Research Article last updated 01/09/2012 - 10:47am.

  8. Allogeneic hematopoetic stem cell transplantation in pediatric myelodysplastic syndromes: Improved outcomes for de novo disease.

    ... patients had a documented cytogenetic abnormality, and monosomy 7 /7q- was seen in 12 patients (52%). Fourteen of 23 patients received a ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. "Moderate" dose cyclophosphamide for severe aplastic anemia has significant toxicity and does not prevent relapse and clonal evolution.

    ... abnormalities were observed in 4 patients, including monosomy 7 . Although cyclophosphamide has activity in SAA, its toxicity is not ...

    Research Article last updated 10/07/2014 - 8:33am.

  10. "Moderate" dose cyclophosphamide for severe aplastic anemia has significant toxicity and does not prevent relapse and clonal evolution

    ... abnormalities were observed in 4 patients, including monosomy 7 . Although cyclophosphamide has activity in SAA, its toxicity is not ...

    Research Article last updated 09/24/2014 - 10:17am.