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  1. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... inhibitor eculizumab , a humanized anti-C5 monoclonal antibody , has been proven safe and effective for the treatment of PNH ...

    Research Article last updated 03/05/2013 - 9:38am.

  2. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... inhibitor eculizumab , a humanized anti-C5 monoclonal antibody , has been proven safe and effective for the treatment of PNH ...

    Research Article last updated 10/02/2012 - 9:57am.

  3. Anti-Complement Treatment in Paroxysmal Nocturnal Hemoglobinuria: Where we Stand and Where we are Going

    ... disease. Indeed, in the last decad the anti-C5 monoclonal antibody has proven effective for the treatment of PNH, resulting in a ...

    Research Article last updated 05/22/2014 - 8:24am.

  4. Reduced intensity conditioning, combined transplantation of haploidentical hematopoietic stem cells and mesenchymal stem cells in patients with severe aplastic anemia

    ... received cyclosporin A, mycophenolatemofetil, and CD25 monoclonal antibody . A total of 16 patients achieved hematopoietic reconstitution. ...

    Research Article last updated 04/09/2014 - 9:16am.

  5. Hematopoietic stem cell transplantation with umbilical cord multipotent stromal cell infusion for the treatment of aplastic anemia-a single-center experience.

    ... mofetil with or without addition of anti-CD25 monoclonal antibody was performed. Hematopoietic engraftment , the occurrence ...

    Research Article last updated 07/09/2013 - 2:48pm.

  6. Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders

    ... clinical hallmark of PNH. In the last decade the anti-C5 monoclonal antibody has been proven effective for the treatment of PNH, resulting in a ...

    Research Article last updated 10/02/2012 - 10:00am.

  7. Successful Use of Eculizumab in a Pediatric Patient Treated for Paroxysmal Nocturnal Hemoglobinuria

    ... reported in children. Eculizumab , a humanized monoclonal antibody targeting and preventing cleavage of the terminal complement ...

    Research Article last updated 07/31/2012 - 12:38pm.

  8. Cotransplantation of allogeneic mesenchymal and hematopoietic stem cells in children with aplastic anemia

    ... and mycophenolate mofetil, with or without anti-CD25 monoclonal antibody . The grafts were granulocyte colony-stimulating ...

    Research Article last updated 07/30/2012 - 1:18pm.

  9. Mechanisms and Clinical Implications of Thrombosis in Paroxysmal Nocturnal Hemoglobinuria

    ... not completely prevent thrombosis. Eculizumab , a monoclonal antibody to complement factor C5, effectively reduces intravascular ...

    Research Article last updated 11/21/2011 - 3:08pm.

  10. Activity of alemtuzumab monotherapy in treatment-naive, relapsed, and refractory severe acquired aplastic anemia

    ... (SAA). We hypothesized that the humanized anti-CD52 monoclonal antibody , alemtuzumab , might be active in SAA due to its ...

    Research Article last updated 11/16/2011 - 1:57pm.