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  1. Small-molecule Factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

    ... that are treated with eculizumab , a humanized monoclonal antibody against the terminal complement component C5. Eculizumab must be ...

    Research Article last updated 11/28/2016 - 11:42am.

  2. Allogeneic stem cell transplantation using alemtuzumab-containing regimens in severe aplastic anemia.

    ... Alemtuzumab , a humanized anti-CD52, IgG1 monoclonal antibody , is used to reduce graft-versus- host disease (GVHD) and aid ...

    Research Article last updated 06/20/2013 - 10:30am.

  3. Eculizumab in Pregnant Patients with Paroxysmal Nocturnal Hemoglobinuria

    ... BACKGROUND: Eculizumab , a humanized monoclonal antibody against complement protein C5 that inhibits terminal complement ...

    Research Article last updated 10/12/2015 - 10:05am.

  4. Eculizumab in the management of paroxysmal nocturnal hemoglobinuria: patient selection and special considerations

    ... The development of eculizumab , a humanized monoclonal antibody directed against the terminal complement protein C5, has resulted ...

    Research Article last updated 09/13/2016 - 1:53pm.

  5. Yttrium Y 90 Anti-CD45 Monoclonal Antibody BC8 Followed by Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome

    ... yttrium Y 90 anti-cluster of differentiation 45 (CD45) monoclonal antibody BC8 (90Y-BC8) followed by donor stem cell transplant in ...

    Clinical Trial last updated 04/28/2016 - 1:11pm.

  6. Iodine I 131 Monoclonal Antibody BC8, Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation and Donor Bone Marrow Transplant in Treating Patients With Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or High-Risk Myelodysplastic Sy

    ... the side effects and best dose of iodine I 131monoclonal antibody BC8 when given together with fludarabine phosphate, ... rejecting the donor's stem cells . Also, radiolabeled monoclonal antibodies, such as iodine I 131 monoclonal antibody BC8, ...

    Clinical Trial last updated 04/28/2016 - 1:01pm.

  7. Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

    ... namely complement blockade through the anti-C5 monoclonal antibody eculizumab . This brief review focuses on two specific ...

    Research Article last updated 06/07/2016 - 10:56am.

  8. Impact of eculizumab treatment on paroxysmal nocturnal hemoglobinuria: A treatment versus no-treatment study

    ... be controlled with eculizumab , a humanized monoclonal antibody that binds complement protein C5. We report here a retrospective ...

    Research Article last updated 04/29/2016 - 10:21am.

  9. Assessing complement blockade in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab

    ... controlled with eculizumab , a humanized monoclonal antibody that binds complement protein C5. The residual functional ...

    Research Article last updated 01/20/2015 - 2:28pm.

  10. Paroxysmal nocturnal hemoglobinuria

    ... syndrome 2. Eculizumab , first-in-class monoclonal antibody that inhibits terminal complement, is the treatment of choice for ...

    Research Article last updated 10/02/2014 - 8:35am.