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  1. Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

    ... source identified for allogeneic transplantation, either related (7/8 or 8/8 allele matched or haploidentical), unrelated (7/8 or 8/8 allele match) donor, or cord ...

    Clinical Trial last updated 07/14/2016 - 4:08pm.

  2. Azacitidine in Haploidentical Donor Hematopoietic Cell Transplantation

    ... however, human leukocyte antigen ( HLA )-matched donor availability continues to be a major hurdle. Historically, HLA ... comparable to allo-HCT using more traditional HLA matched related and unrelated donors. However, graft-versus-host disease (GvHD) ...

    Clinical Trial last updated 05/03/2016 - 11:15am.

  3. Selective Depletion of CD45RA+ Naive T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors for Prevention of GVHD

    ... myeloid leukemia, or chronic myelogenous leukemia undergoing donor peripheral blood stem cell transplant . Giving chemotherapy ... of induction chemotherapy) Other acute leukemia or related neoplasm (including but not limited to 'biphenotypic', ... the principal investigator Patient with a HLA -matched (HLA-A, B, C, and DRB1 molecularly matched) unrelated donor or ...

    Clinical Trial last updated 06/06/2016 - 2:55pm.

  4. Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

    ... event rate for failed donor engraftment or treatment related mortality (TRM) at day 100 exceeds 20 percent. The primary endpoint ... or single HLA locus mismatched family donor or 10/10 matched unrelated donor at the allelic level (HLA alleles A, B, C, DR, ...

    Clinical Trial last updated 04/28/2016 - 2:40pm.

  5. Stem Cell Transplant Using Peripheral and Cord Blood Stem Cells to Treat Severe Aplastic Anemia and Myelopdysplastic Syndrome

    ... bone marrow transplantation from either HLA -matched sibling or matched unrelated donor cures about 70 percent of ... which contributes to infection and transplant related mortality (TRM). In order to harness the advantage of UCB availability ...

    Clinical Trial last updated 04/25/2016 - 2:18pm.

  6. RIC Transplant Using Haplo Donors

    ... Criteria:  No available matched related or unrelated donor , OR a matched related or unrelated donor ...

    Clinical Trial last updated 04/29/2016 - 10:52am.

  7. Allo HSCT Using RIC for Hematological Diseases

    ... body irradiation (TBI) preparative regimen followed by a related or unrelated donor stem cell infusion. The primary objective is ... related donor match or a 7-8/8 HLA -A,B,C,DRB1 allele matched unrelated donor marrow and/or PBSC donor match per current ...

    Clinical Trial last updated 05/02/2016 - 9:29am.

  8. Intensity Modulated Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients With Relapsed Hematologic Cancers Undergoing a Second Donor Stem Cell Transplant

    ... already had first allo-SCT; in the majority time, the same matched donor has been used for second allo-SCT; if the patients have multiple ... be used for the second allo-SCT; the donor could be matched related donors or matched unrelated donors from registry DONOR: If more ...

    Clinical Trial last updated 05/23/2016 - 2:06pm.

  9. Myeloablative Unrelated Donor Cord Blood Transplantation With T-Cell Depleted Haplo-identical Peripheral Blood Stem Cells for Patients With High Risk Hematological Malignancies

    ... de novo acute leukemia or acute leukemia that is therapy related or arising from an antecedent hematologic disorder including ... be selected as available Mismatched family members who are matched at more than 5 of 10 HLA-loci are permitted. Factors to be taken into ...

    Clinical Trial last updated 04/29/2016 - 1:33pm.

  10. Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD in Children

    ... acid [RNA] binding motif protein 45 [DRB1] molecularly matched) unrelated donor or related donor capable of donating PBSC DONOR: HLA-matched unrelated donors ...

    Clinical Trial last updated 06/13/2016 - 2:29pm.