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  1. Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant

    ... patients had haploidentical donors (HIDs), and 69 had matched related donors (MRDs) for HSCT. The median times for myeloid engraftment ...

    Research Article last updated 02/03/2017 - 9:40am.

  2. Alternative donors for allogeneic hematopoietic stem cell transplantation in poor-risk AML in CR1

    ... with poor-risk AML in CR1 receiving an alloHSCT using matched related donor (MRD, n = 3511) or alternative donors, including 10/10 (n = ...

    Research Article last updated 03/09/2017 - 8:22am.

  3. Overcoming age barrier to transplantation

    ... for a source of cells. Since a minority of patients have a matched sibling donor, success often depends on transplants from an unrelated ... the costs of acquiring those organs separately from the related inpatient care. By reimbursing acquisition on a reasonable cost basis, ...

    Article last updated 04/03/2017 - 2:00pm.

  4. Drug reduces acute GVHD in unrelated HSCTs

    ... graft-versus-host disease (GVHD) in the setting of matched unrelated donor myeloablative conditioning hematopoietic ... and resulted in a low incidence of acute GVHD following related donor-reduced intensity conditioning HSCT.2 In the phase II trial, ...

    Article last updated 02/27/2017 - 1:45pm.

  5. Strong results for SAA patients at Johns Hopkins

    ... called severe aplastic anemia using partially matched bone marrow transplants followed by two high doses of a common ... therapy or other drug treatments. None had access to a related fully matched bone marrow donor but did have an available and willing ...

    Article last updated 02/07/2017 - 11:05am.

  6. Pilot trial of risk-adapted cyclophosphamide intensity based conditioning and HLA matched sibling and unrelated cord blood stem cell transplantation in newly diagnosed pediatric and adolescent recipients with acquired severe aplastic anemia

    ... hematopoietic stem cell transplantation (AlloHSCT) from matched related donors (MRD) has resulted in the highest survival rates in children ...

    Research Article last updated 04/09/2014 - 9:11am.

  7. First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia.

    ... cells is a first-line treatment option if HLA -matched related donors are available. First-line immunosuppressive therapy may ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Recent developments in bone marrow transplants

    ... increased risk for graft-versus-host disease (GVHD)–related mortality in adults with T-cell leukemia/lymphoma. Patients with ... of a HSCT from an umbilical cord blood source or HLA–matched unrelated donor . Repeated infusions of mesenchymal stromal ...

    Article last updated 11/16/2016 - 2:56pm.

  9. Retrospective study of alemtuzumab vs ATG-based conditioning without irradiation for unrelated and matched sibling donor transplants in acquired severe aplastic anemia: a study from the British Society for Blood and Marrow Transplantation.

    ... patients received alemtuzumab and 55 ATG-based regimens. A matched sibling donor (MSD) was used in 87 (56%), matched unrelated donor (MUD) in 60 (39%) and other related or mismatched unrelated donor (UD) in 8 (5%) patients. Engraftment ...

    Research Article last updated 08/15/2013 - 9:45am.

  10. Impact of donor source on hematopoietic cell transplantation outcomes for patients with myelodysplastic syndromes (MDS)

    ... (HCT) from human leukocyte antigen ( HLA ) matched related donor (MRD) and matched unrelated donors (MUD) produces similar ...

    Research Article last updated 08/06/2013 - 2:12pm.