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  1. Foundation Update - October 2017

    ... epitome of resilience as she has waited for years to find a matched donor. She has devoted this time to helping other patients by enlarging ... been added on personalized medicine and the fundamentals of related diseases, such as AML, CMML, GVHD, MPNs and PRCA. The remaining 2017 ...

    Article last updated 11/30/2017 - 2:30pm.

  2. Repurposing older drugs to help prevent GVHD

    ... disease (GVHD) after reduced-intensity conditioning, related donor hematopoietic cell transplantation (HCT). However, its safety and ... receive myeloablative HCT from an available 8/8- HLA matched URD. Patients received GVHD prophylaxis with tacrolimus and ...

    Article last updated 10/18/2017 - 8:48am.

  3. Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant

    ... patients had haploidentical donors (HIDs), and 69 had matched related donors (MRDs) for HSCT. The median times for myeloid engraftment ...

    Research Article last updated 02/03/2017 - 9:40am.

  4. Alternative donors for allogeneic hematopoietic stem cell transplantation in poor-risk AML in CR1

    ... with poor-risk AML in CR1 receiving an alloHSCT using matched related donor (MRD, n = 3511) or alternative donors, including 10/10 (n = ...

    Research Article last updated 03/09/2017 - 8:22am.

  5. Stem Cell Transplantation: What Happens Behind the Scenes?

    ... Match®) registry and from this, I can identify unrelated matched donors or cord blood units for the recipient. Here at NIH, I work with ... the HLA and typing laboratories, the apheresis center when related donors are involved, radiology, molecular hematology, and so much more. ...

    Interview last updated 01/18/2018 - 1:28pm.

  6. Pilot trial of risk-adapted cyclophosphamide intensity based conditioning and HLA matched sibling and unrelated cord blood stem cell transplantation in newly diagnosed pediatric and adolescent recipients with acquired severe aplastic anemia

    ... hematopoietic stem cell transplantation (AlloHSCT) from matched related donors (MRD) has resulted in the highest survival rates in children ...

    Research Article last updated 04/09/2014 - 9:11am.

  7. First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia.

    ... cells is a first-line treatment option if HLA -matched related donors are available. First-line immunosuppressive therapy may ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... count < 20 x10^9/L No suitable fully matched related (6/6 match for human leukocyte antigen ( HLA )-A and B at ...

    Clinical Trial last updated 12/19/2017 - 7:55am.

  9. Retrospective study of alemtuzumab vs ATG-based conditioning without irradiation for unrelated and matched sibling donor transplants in acquired severe aplastic anemia: a study from the British Society for Blood and Marrow Transplantation.

    ... patients received alemtuzumab and 55 ATG-based regimens. A matched sibling donor (MSD) was used in 87 (56%), matched unrelated donor (MUD) in 60 (39%) and other related or mismatched unrelated donor (UD) in 8 (5%) patients. Engraftment ...

    Research Article last updated 08/15/2013 - 9:45am.

  10. Overcoming age barrier to transplantation

    ... for a source of cells. Since a minority of patients have a matched sibling donor, success often depends on transplants from an unrelated ... the costs of acquiring those organs separately from the related inpatient care. By reimbursing acquisition on a reasonable cost basis, ...

    Article last updated 04/03/2017 - 2:00pm.