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  1. Repurposing older drugs to help prevent GVHD

    ... disease (GVHD) after reduced-intensity conditioning, related donor hematopoietic cell transplantation (HCT). However, its safety and ... receive myeloablative HCT from an available 8/8- HLA matched URD. Patients received GVHD prophylaxis with tacrolimus and ...

    Article last updated 10/18/2017 - 8:48am.

  2. Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant

    ... patients had haploidentical donors (HIDs), and 69 had matched related donors (MRDs) for HSCT. The median times for myeloid engraftment ...

    Research Article last updated 02/03/2017 - 9:40am.

  3. Alternative donors for allogeneic hematopoietic stem cell transplantation in poor-risk AML in CR1

    ... with poor-risk AML in CR1 receiving an alloHSCT using matched related donor (MRD, n = 3511) or alternative donors, including 10/10 (n = ...

    Research Article last updated 03/09/2017 - 8:22am.

  4. First-in Human Clinical Transplant Trial for Severe Aplastic Anemia

    ... we began aimed at helping patients that did not have an HLA matched donor started about 12 years ago. This is when we tried to come up with ... rates that are comparable with those from the fully matched, related donors. The idea now is that if we can get much higher number of ...

    Interview last updated 10/04/2017 - 1:36pm.

  5. Overcoming age barrier to transplantation

    ... for a source of cells. Since a minority of patients have a matched sibling donor, success often depends on transplants from an unrelated ... the costs of acquiring those organs separately from the related inpatient care. By reimbursing acquisition on a reasonable cost basis, ...

    Article last updated 04/03/2017 - 2:00pm.

  6. Pilot trial of risk-adapted cyclophosphamide intensity based conditioning and HLA matched sibling and unrelated cord blood stem cell transplantation in newly diagnosed pediatric and adolescent recipients with acquired severe aplastic anemia

    ... hematopoietic stem cell transplantation (AlloHSCT) from matched related donors (MRD) has resulted in the highest survival rates in children ...

    Research Article last updated 04/09/2014 - 9:11am.

  7. Drug reduces acute GVHD in unrelated HSCTs

    ... graft-versus-host disease (GVHD) in the setting of matched unrelated donor myeloablative conditioning hematopoietic ... and resulted in a low incidence of acute GVHD following related donor-reduced intensity conditioning HSCT.2 In the phase II trial, ...

    Article last updated 02/27/2017 - 1:45pm.

  8. First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia.

    ... cells is a first-line treatment option if HLA -matched related donors are available. First-line immunosuppressive therapy may ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. Strong results for SAA patients at Johns Hopkins

    ... called severe aplastic anemia using partially matched bone marrow transplants followed by two high doses of a common ... therapy or other drug treatments. None had access to a related fully matched bone marrow donor but did have an available and willing ...

    Article last updated 02/07/2017 - 11:05am.

  10. Retrospective study of alemtuzumab vs ATG-based conditioning without irradiation for unrelated and matched sibling donor transplants in acquired severe aplastic anemia: a study from the British Society for Blood and Marrow Transplantation.

    ... patients received alemtuzumab and 55 ATG-based regimens. A matched sibling donor (MSD) was used in 87 (56%), matched unrelated donor (MUD) in 60 (39%) and other related or mismatched unrelated donor (UD) in 8 (5%) patients. Engraftment ...

    Research Article last updated 08/15/2013 - 9:45am.