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  1. A Marked Decrease in CD4-Positive Lymphocytes at the Onset of Hepatitis in a Patient With Hepatitis-Associated Aplastic Anemia.

    ... especially CD4 T-lymphocytopenia. Although the total lymphocyte counts rose as the patient recovered from hepatitis, this was ... treated with immunosuppressive therapy, which normalized the lymphocyte subset proportions. T-cell subsets analysis at the onset of ...

    Research Article last updated 04/26/2012 - 8:44am.

  2. Donor Lymphocyte Infusion (DLI) of T-cells Genetically Modified With iCasp9 Suicide Gene

    ... of GVHD, occurring within 60 days of the planned donor lymphocyte infusion. Exclusion Criteria:  ... Filgrastim Neupogen Procedure: Donor Lymphocyte Infusion (DLI) iCasp9 (BPZ-1001)-Modified T-cells) of 3 X ...

    Clinical Trial last updated 06/06/2016 - 12:41pm.

  3. New therapeutic approaches for protecting hematopoietic stem cells in aplastic anemia.

    ... AA was reproduced in animals, including mouse lymphocyte infusion models, which are used to study further etiology ... and significantly decrease the loss of HSCs in mouse lymphocyte infusion model of AA. Bone Marrow ...

    Research Article last updated 11/14/2013 - 11:18am.

  4. First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia.

    ... very severe aplastic anemia, and combination of anti- lymphocyte globulin with cyclosporine A were factors for improved ... without very severe aplastic anemia, and combination of anti-lymphocyte globulin with cyclosporine A were factors for improved survival in ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Analysis of allogeneic hematopoietic stem cell transplantation with high-dose cyclophosphamide-induced immune tolerance for severe aplastic anemia

    ... by the evidence of 100 % donor hematopoiesis ; T lymphocyte subset counts also increased significantly after ...

    Research Article last updated 11/01/2016 - 1:59pm.

  6. Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia

    ... T cells (TSCMs) constitute a long-lived, self-renewing lymphocyte population essential for the maintenance of functional immunity. ...

    Research Article last updated 04/29/2016 - 12:59pm.

  7. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells

    ... deficient progenitor cells, a novel T lymphocyte enrichment culture assay with proaerolysin selection to expand ... T lymphocytes and 3 of them were detected only after T lymphocyte enrichment in proaerolysin selection. PIG-A mutation analyses on 3 ...

    Research Article last updated 06/15/2012 - 1:48pm.

  8. Immune markers of disease severity and treatment response in pediatric acquired aplastic anemia

    ... 2/6 PNH(neg) patients had a CR and 4/6 had a PR. Lymphocyte subset immunophenotyping revealed that T-regulatory cells ...

    Research Article last updated 07/31/2012 - 2:10pm.

  9. Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria: results of a bone marrow failure consortium study.

    ... Large granular lymphocyte (LGL) leukemia is characterized by clonal expansion of ...

    Research Article last updated 07/30/2012 - 2:51pm.

  10. Paroxysmal nocturnal hemoglobinuria

    ... Large granular lymphocyte (LGL) leukemia is characterized by clonal expansion of ...

    Research Article last updated 07/30/2012 - 2:21pm.