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  1. Positive Impact of Eculizumab Therapy on Surgery for Budd-Chiari Syndrome in a Patient with Paroxysmal Nocturnal Hemoglobinuria and a Long-Term History of Thrombosis

    ... bleeding, hematuria, and elevated plasma lactate dehydrogenase ; he started eculizumab therapy with a good response. ...

    Research Article last updated 11/02/2016 - 2:49pm.

  2. Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan

    ... hemolysis was demonstrated by a reduction in lactate dehydrogenase levels at all measurements after baseline. Significant ...

    Research Article last updated 11/02/2016 - 10:39am.

  3. The dysfunction of platelets in paroxysmal nocturnal hemoglobinuria

    ... higher in PNH/PNH-AA patients - especially those with lactate dehydrogenase (LDH) concentrations>1000U/L - than in controls (P<0.05). ...

    Research Article last updated 11/02/2016 - 10:37am.

  4. Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan

    ... hemolysis was demonstrated by a reduction in lactate dehydrogenase levels at all measurements after baseline. Significant ...

    Research Article last updated 08/15/2016 - 9:10am.

  5. Predictors of Hemoglobin Response to Eculizumab Therapy in Paroxysmal Nocturnal Hemoglobinuria

    ... hemoglobin for age/sex, absence of symptoms, and lactate dehydrogenase < 1.5 times the upper limit of normal. A good partial ...

    Research Article last updated 11/05/2012 - 10:28am.

  6. Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine.

    ... immunosuppressive therapy did not have an elevated lactate dehydrogenase , nor did they experience hemolysis or thrombosis ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Chronic treatment of paroxysmal nocturnal hemoglobinuria patients with eculizumab: safety, efficacy, and unexpected laboratory phenomena

    ... requirements, and serum iron parameters were analyzed. Lactate dehydrogenase levels were significantly decreased by 85% from a median of ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Efficacy and safety of eculizumab in children and adolescents with paroxysmal nocturnal hemoglobinuria

    ... of hemolysis in all participants with a reduction of lactate dehydrogenase to normal levels. All hematological parameters stabilized. No ...

    Research Article last updated 05/22/2014 - 8:29am.

  9. Revised International Prognostic Scoring System (IPSS) Predicts Survival and Leukemic Evolution of Myelodysplastic Syndromes Significantly Better Than IPSS and WHO Prognostic Scoring System: Validation by the Gruppo Romano Mielodisplasie Italian Regional

    ... The multivariate analysis, including IPSS, WPSS, age, lactate dehydrogenase , ferritin concentration, Eastern Cooperative Oncology ...

    Research Article last updated 08/07/2013 - 9:18am.

  10. A prospective multicenter study of paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure.

    ... other BMF (24.4%), and the percentage of patients with lactate dehydrogenase levels (a marker for intravascular hemolysis) ≥ 1.5 × ...

    Research Article last updated 11/21/2013 - 11:54am.