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  1. Efficacy and safety of deferasirox in myelodysplastic syndromes

    ... damage due to accumulation of non- transferrin -bound iron with consequent increased oxidative stress. Iron chelation has been ... plasma iron, independently from the efficacy on iron overload . Deferasirox is a potent NF-kB inhibitor, tested in vivo and on ...

    Research Article last updated 03/05/2013 - 9:15am.

  2. Research and Education Council

    ... (e.g., blood clotting/ thrombosis in PNH, iron overload in MDS, etc). Members support the Council with personal ...

    Page last updated 06/20/2017 - 9:22am.

  3. SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes

    ... the presence of abnormal sideroblasts characterized by iron overload in the mitochondria, called RS. Based on the high frequency of ...

    Research Article last updated 07/31/2012 - 12:50pm.

  4. Prospective assessment of effects on iron-overload parameters of deferasirox therapy in patients with myelodysplastic syndromes.

    ... evaluating the effects of deferasirox on liver iron concentration (LIC), labile plasma iron (LPI) and pharmacokinetics (PK) along with serum ferritin values ... syndromes (MDS) and evidence of iron overload . Twenty-four heavily transfused MDS patients were enrolled in a ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. How we treat lower risk myelodysplastic syndromes.

    ... correction of anemia , alloimmunization, and organ iron overload (for which the role of iron chelation remains debated). Treatment ...

    Research Article last updated 05/14/2013 - 2:56pm.

  6. Supportive care in severe and very severe aplastic anemia

    ... bacterial and viral infections, transfusion strategy and iron chelation and assess the evidence basis. In fact, many recommendations for ... events like alloimmunization to blood products and iron overload have a significant impact on the prognosis of AA patients and need ...

    Research Article last updated 01/02/2013 - 2:32pm.

  7. Infections in myelodysplastic syndromes: a review

    ... T-, and NK-cell defects and the possible consequences of iron overload due to red blood cell transfusions. The advanced age of ...

    Research Article last updated 07/31/2012 - 1:39pm.

  8. The clinical, quality of life, and economic consequences of chronic anemia and transfusion support in patients with myelodysplastic syndromes

    ... and quality of life (QoL), and are associated with iron overload , potentially leading to organ damage. QoL studies demonstrate that ...

    Research Article last updated 06/15/2012 - 2:03pm.

  9. Chronic treatment of paroxysmal nocturnal hemoglobinuria patients with eculizumab: safety, efficacy, and unexpected laboratory phenomena

    ... of hemolysis , transfusion requirements, and serum iron parameters were analyzed. Lactate dehydrogenase levels were ... iron depletion therapy should be considered in the case of overload. Bone Marrow Diseases:  ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. Iron Overload and MDS

    PubMed Abstract:  Iron overload and chelation therapy in myelodysplastic syndromes ...

    Research Review last updated 05/02/2016 - 9:18am.