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  1. Distinct iron architecture in SF3B1 mutant myelodysplastic syndromes patients is linked to an SLC25A37 splice variant with a retained intron

    ... Perturbation in iron homeostasis is a hallmark of some hematologic diseases. Abnormal ... that SF3B1 mutations contribute to cellular iron overload in RARS/-T by deregulating SLC25A37.Leukemia accepted article ...

    Research Article last updated 06/02/2014 - 10:42am.

  2. Comparison of 24-month outcomes in chelated and non-chelated lower-risk patients with myelodysplastic syndromes in a prospective registry

    ... 600 lower-risk MDS patients (pts) with transfusional iron overload . Clinical outcomes were compared between chelated and nonchelated ...

    Research Article last updated 01/08/2014 - 9:35am.

  3. Iron status and treatment modalities in transfusion-dependent patients with myelodysplastic syndromes.

    ... Transfusion dependency and iron overload are common among patients with myelodysplastic syndromes ...

    Research Article last updated 10/11/2011 - 5:58pm.

  4. Iron chelation therapy in myelodysplastic syndromes.

    ... transfusion dependency can be long lasting, leading to iron overload . Iron chelation therapy may be a therapeutic option for ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Clinical management of gastrointestinal disturbances in patients with myelodysplastic syndromes receiving iron chelation treatment with deferasirox

    ... of packed red blood cells leading to a secondary iron overload which might result in organ damage. Therefore, sufficient iron ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. The role of iron chelation therapy for patients with myelodysplastic syndromes.

    ... The appropriate role of iron chelation therapy in the management of patients with ... with evidence suggesting transfusion-associated iron overload , is an important component of high-quality MDS patient care. Other ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Increased parameters of oxidative stress and its relation to transfusion iron overload in patients with myelodysplastic syndromes.

    Journal Title:  J Clin Pathol Primary Author:  de Souza GF Author(s):  de Sou...

    Research Article last updated 06/28/2013 - 1:33pm.

  8. Iron overload in myelodysplastic syndromes. Introduction.

    Journal Title:  Am J Health Syst Pharm Primary Author:  Harvey RD Author(s):  ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. Iron overload in myelodysplastic syndromes.

    Journal Title:  Expert Rev Hematol Primary Author:  Chodirker L Author(s):  C...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. Efficacy and safety of deferasirox in myelodysplastic syndromes

    ... damage due to accumulation of non- transferrin -bound iron with consequent increased oxidative stress. Iron chelation has been ... plasma iron, independently from the efficacy on iron overload . Deferasirox is a potent NF-kB inhibitor, tested in vivo and on ...

    Research Article last updated 03/05/2013 - 9:15am.