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  1. PNH 101: Understanding Diagnosis and Treatment

    ... went over treatment options, including eculizumab , immunosuppressive drug therapy, stem cell transplantation, and supportive therapies like ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  2. Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia

    ... cyclosporine , prednisone > 20mg/day, or immunosuppressive agents DONOR: Personal or family history of severe sickle ... Intervention:  Drug: mitoxantrone hydrochloride Given IV Other Names: CL ...

    Clinical Trial last updated 06/13/2016 - 3:31pm.

  3. Eltrombopag in aplastic anemia

    ... marrow failure in most cases. Its treatment is based on immunosuppressive strategies, whether via allogeneic bone marrow ... recent eltrombopag studies. Eltrombopag is a synthetic drug that mimics thrombopoietin (TPO) effect, a hematopoietic growth factor ...

    Research Review last updated 05/02/2016 - 9:13am.

  4. Extended Dosing With Eltrombopag for Severe Aplastic Anemia

    ... blood disease that can be successfully treated with immunosuppressive drug regimens or allogeneic stem cell transplantation. However, 20-40% of ... thrombocytopenia following standard immunosuppressive therapy. Patients began at a dose of 50 mg/day and escalated every two weeks to ...

    Clinical Trial last updated 04/26/2016 - 9:36am.

  5. Safety and Effect of GL-ONC1 Administered IV With or Without Eculizumab Prior to Surgery to Patients With Solid Organ Cancers Undergoing Surgery

    ... experimental because it is not approved by the Food and Drug Administration (FDA) for the treatment of any disease. Eculizumab is ... study treatment. Patients who are receiving additional immunosuppressive therapy or any steroids (except concurrent corticosteroid ...

    Clinical Trial last updated 04/28/2016 - 1:57pm.

  6. Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia

    ... Comparable long-term survival in SAA is attainable with immunosuppressive treatment with horse anti-thymocyte globulin (h-ATG) and ... neutrophil count. When responders continued the drug beyond three months, the hematologic response to eltrombopag increased; a ...

    Clinical Trial last updated 04/25/2016 - 2:47pm.

  7. Aplastic Anemia Clinical Trial at the NIH

    ... eltrombopag (also known as Promacta®). Eltrombopag is a drug designed to mimic a special protein in the body called thrombopoietin ... with severe aplastic anemia who failed to respond to prior immunosuppressive therapy were subsequently treated with eltrombopag, 44% ...

    Research Review last updated 05/02/2016 - 9:26am.

  8. European Study of Horse ATG vs. Rabbit ATG for Treatment of Aplastic Anemia

    ... the immune system, specifically the T-lymphocytes. The best immunosuppressive therapy for patients with severe aplastic anemia (sAA) is a ... a Phase 2 study is a clinical trial whereby a drug is given to a patient with the intent of knowing whether the patient will ...

    Research Review last updated 05/02/2016 - 9:31am.

  9. New therapeutics for myelodysplastic syndromes

    ... Dr. List outlines the rationale for MDS-directed drug development efforts and describes several emerging agents currently or ... Historically, this approach has consisted primarily of immunosuppressive therapy and been restricted in effectiveness to early stage ...

    Research Review last updated 05/02/2016 - 9:28am.

  10. PNH - Treatment (OLD)

    ... available. It was recently approved to treat PNH. This drug is Eltrombopag (Promacta ®), a synthetic drug that mimics thrombopoetin, ... given as first line treatment for PNH, along with standard immunosuppressive therapy with ATG and cyclosporine . ...

    Topic section last updated 03/10/2016 - 11:09pm.