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  1. Eculizumab

    ... system, to be less active. By doing this it reduces hemolysis , the destruction of red blood cells, in patients with PNH. It is ...

    Drug last updated 03/24/2016 - 12:32pm.

  2. Diagnosis

    ... blood can mean that red blood cells are breaking apart ( hemolysis ) or that there is tissue damage in the body. It is important for ...

    Topic section last updated 03/10/2016 - 11:04pm.

  3. A Trial to Evaluate Two Schedules of MS275 in Combination With 5AC in Elderly Patients With Acute Myeloid Leukemia (AML)

    ... bilirubin within institutional limits unless due to hemolysis , Gilbert's syndrome, or ineffective erythropoiesis. ...

    Clinical Trial last updated 06/03/2016 - 3:09pm.

  4. Phase I/II MAHCT w/ TCell Depleted Graft w/ Simultaneous Infusion Conventional and Regulatory T Cell

    ... may be included at the discretion of the PI or where hemolysis has been excluded Availability of an 6/6 HLA matched ...

    Clinical Trial last updated 05/09/2016 - 3:58pm.

  5. Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia

    ... ≤ 3.0 mg/dL (unless due to Gilbert's syndrome or hemolysis ), and ALT and AST ≤ 5 x ULN FEV1 and FVC > or = to 40% of ...

    Clinical Trial last updated 06/06/2016 - 2:42pm.

  6. What are the treatments for PNH?

    ... , which is part of your immune system. This reduces hemolysis , the destruction of red blood cells. Bone marrow/stem cell ...

    FAQ last updated 03/15/2016 - 11:32pm.

  7. Genetic Polymorphism of the Complement Receptor-1 (CR1) Gene Correlates with the Clinical Response to Eculizumab of Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... of patients,  there is something called “extravascular hemolysis” which is keeping the hemoglobin from recovering fully. Here the ... factors at play in the group that had “extravascular hemolysis”. In fact, there is a gene called, CR1, which controls complement ...

    Research Review last updated 05/02/2016 - 9:25am.

  8. Phase I/II MEK162 Relapsed and/or Refractory Acute Myeloid Leukemia (AML) and Poor Prognosis, Not Suitable for or Unwilling to Receive Standard Therapy

    ... > 1.5 x ULN unless related to Gilbert's syndrome or hemolysis , AST and/or ALT > 2.5 X ULN, or for subjects with liver ...

    Clinical Trial last updated 06/06/2016 - 10:59am.

  9. Special Issues for People with PNH

    ... , there are also a few case reports of flares of hemolysis (when red blood cells are destroyed) after receiving a flu shot. ... are not the same as randomized clinical trials, one case of hemolysis was severe enough to put the patient in the hospital. Thus some ...

    Page last updated 01/20/2015 - 4:59pm.

  10. RIC Transplant Using Haplo Donors

    ... liver function: bilirubin >2 mg/dl (not due to hemolysis , Gilbert's or primary malignancy) poor renal function: ...

    Clinical Trial last updated 04/29/2016 - 10:52am.