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  1. Understanding the Compliment System and the PNH Clone

    ... to help fight infection and how it specifically causes hemolysis in PNH patients. He will also discuss things that can potentially ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  2. Advanced Understanding of PNH in 2015: Hemolytic Anemia, Pancytopenia, and Thrombosis

    ... Although some of the features of this disease, such as hemolysis inside of the blood vessels or appearance of red urine, have been ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  3. PNH: Understanding Hemolytic Anemia, Pancytopenia, and Thrombosis

    ... The symptoms you may experience as a result of hemolysis , pancytopenia, and thrombosis Common PNH treatments to stop or ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  4. Novel Complement Modulators for Paroxysmal Nocturnal Hemoglobinuria: Peptide and Protein Inhibitors of C3 Convertase Prevent Both Surface C3 Deposition and Subsequent Hemolysis of Affected Erythrocytes in Vitro

    ... destroyed in the spleen. This is known as extravascular hemolysis . This study by a group in Italy examined two artificial ... that both of these proteins have the potential to turn off hemolysis, at least in the test tube. Because they both work at an early stage ...

    Research Review last updated 05/02/2016 - 9:25am.

  5. Eculizumab Protects Against TE and Prolongs Survival in Patients with Paroxysmal Nocturnal Hemoglobinuria: An International PNH Registry Study

    ... have shown that eculizumab (Soliris®) reduces rates of hemolysis , or the destruction of platelets, and thromboembolism. The ... Recent red blood cell transfusions, which can indicate hemolysis, were associated with a greater risk of thromboembolism. Not ...

    Research Review last updated 05/02/2016 - 9:26am.

  6. Myelodysplastic Syndromes and autoimmune disorders: Cause or consequence?

    ... seronegative arthritis, panarteritis nodosa, autoimmune hemolysis , and pernicious anemia . Those with both MDS and AD ...

    Research Review last updated 05/02/2016 - 9:18am.

  7. Prednisone

    ... For PNH, it may be used to decrease hemolysis caused by PNH. It may make the complement system less active. Prednisone does not stop all hemolysis, however, and it does have a lot side effects, especially if taken ...

    Topic section last updated 03/10/2016 - 11:27pm.

  8. PNH - Basics

    ... cells to break apart. Doctors call this breaking apart " hemolysis ." It happens because the surface of a person’s blood cells ...

    Topic section last updated 04/05/2016 - 4:02pm.

  9. Insights into the Natural History of Paroxysmal Nocturnal Hemoglobinuria (PNH): Analysis of the Presenting Clinical, Haematological and Flow Cytometric Features of 705 Patients Leads to Improved Classification and Prediction of Clinical Course

    ... Only 10 of 154 patients with aplastic anemia developed hemolysis (premature destruction of red blood cells), and all of these ... that were larger than 5%. In 44% of patients with hemolysis when they entered the study, PNH white blood cell clones continued to ...

    Research Review last updated 05/02/2016 - 9:20am.

  10. Eculizumab

    ... Reduce the breaking apart of red blood cells ( hemolysis ) over both the short and the long term Reduce the risk of blood ...

    Topic section last updated 03/29/2016 - 7:20pm.