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  1. Phase I/II MAHCT w/ TCell Depleted Graft w/ Simultaneous Infusion Conventional and Regulatory T Cell

    ... may be included at the discretion of the PI or where hemolysis has been excluded Availability of an 6/6 HLA matched ...

    Clinical Trial last updated 05/09/2016 - 3:58pm.

  2. Insights into the Natural History of Paroxysmal Nocturnal Hemoglobinuria (PNH): Analysis of the Presenting Clinical, Haematological and Flow Cytometric Features of 705 Patients Leads to Improved Classification and Prediction of Clinical Course

    ... Only 10 of 154 patients with aplastic anemia developed hemolysis (premature destruction of red blood cells), and all of these ... that were larger than 5%. In 44% of patients with hemolysis when they entered the study, PNH white blood cell clones continued to ...

    Research Review last updated 05/02/2016 - 9:20am.

  3. Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders (BMT)

    ... bilirubin < 2.0 (unless diagnosis of Gilbert's or hemolysis is made) and AST, ALT, alkaline phosphatase all < 5x institutions ...

    Clinical Trial last updated 05/09/2016 - 3:36pm.

  4. Genetic Polymorphism of the Complement Receptor-1 (CR1) Gene Correlates with the Clinical Response to Eculizumab of Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... of patients,  there is something called “extravascular hemolysis” which is keeping the hemoglobin from recovering fully. Here the ... factors at play in the group that had “extravascular hemolysis”. In fact, there is a gene called, CR1, which controls complement ...

    Research Review last updated 05/02/2016 - 9:25am.

  5. Disease Won't Run My Life

    ... to my PNH, my red blood cells had been merrily bursting ( hemolysis ), with no concern for me.  Occasionally, I was having PNH ...

    Patient Chronicle last updated 05/10/2016 - 3:36pm.

  6. RIC Transplant Using Haplo Donors

    ... liver function: bilirubin >2 mg/dl (not due to hemolysis , Gilbert's or primary malignancy) poor renal function: ...

    Clinical Trial last updated 04/29/2016 - 10:52am.

  7. Shorter Course Tacrolimus After Nonmyeloablative, Related Donor BMT With High-dose Posttransplantation Cyclophosphamide

    ... equal to 3.0 mg/dL (unless due to Gilbert's syndrome or hemolysis ), and ALT and AST greater than or equal to 5 x ULN FEV1 and ...

    Clinical Trial last updated 05/02/2016 - 2:38pm.

  8. Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders

    ... of their disease including thrombotic events, severe hemolysis or Budd Chiari syndrome are eligible; other patients may be ...

    Clinical Trial last updated 04/28/2016 - 2:45pm.

  9. Nonmyeloablative Haploidentical Transplant Followed by MLN9708

    ... liver function: bilirubin >2.5 mg/dl (not due to hemolysis , Gilbert's or primary malignancy), AST/ALT > 3X ULN Poor ...

    Clinical Trial last updated 04/29/2016 - 1:05pm.

  10. Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET)

    ... beyond 1.5 x ULN due to documented Gilbert's syndrome or hemolysis may be included). No detectable PNH ( paroxysmal nocturnal ...

    Clinical Trial last updated 05/02/2016 - 2:31pm.