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  1. Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemia.

    ... PNH clone size and the development of intravascular hemolysis , assessed by LDH values (Pearson Correlation Coefficient=0.80, ... granulocyte PNH size of 23% were the thresholds to predict hemolysis as measured by an elevated LDH (ROC analyses with AUC=0.96 for ...

    Research Article last updated 10/11/2011 - 5:58pm.

  2. How I treat paroxysmal nocturnal hemoglobinuria.

    ... disease result from complement-mediated intravascular hemolysis . Allogeneic bone marrow transplantation is the only curative ... complement activation, is highly effective in reducing hemolysis, improving quality of life, and reducing the risk for thrombosis in ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape

    ... susceptible to complement attack. Intravascular hemolysis via the membrane attack complex is a clinical hallmark of the ...

    Research Article last updated 09/24/2014 - 10:07am.

  4. Symptoms

    ... Hemolysis Hemolysis is the breaking apart of red blood cells. Hemolysis happens when ...

    Topic section last updated 03/29/2016 - 6:18pm.

  5. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... the clone more sensitive to complement mediated hemolysis . The diagnosis of PNH may be difficult in some cases due a low ...

    Research Article last updated 10/22/2013 - 3:44pm.

  6. Predictors of Hemoglobin Response to Eculizumab Therapy in Paroxysmal Nocturnal Hemoglobinuria

    ... has been shown to improve anemia, decrease intravascular hemolysis and reduce the risk of thrombosis . DESIGN AND METHODS: ...

    Research Article last updated 11/05/2012 - 10:28am.

  7. Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders

    ... a sustained control of complement-mediated intravascular hemolysis , with a remarkable clinical benefit. Since then, different ...

    Research Article last updated 10/02/2012 - 10:00am.

  8. Successful Use of Eculizumab in a Pediatric Patient Treated for Paroxysmal Nocturnal Hemoglobinuria

    ... C5, has become the "gold standard" of treatment for hemolysis or significant disease-related complications in patients with ...

    Research Article last updated 07/31/2012 - 12:38pm.

  9. Eculizumab: a guide to its use in paroxysmal nocturnal hemoglobinuria

    ... eculizumab (Soliris) reduces intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria ...

    Research Article last updated 07/30/2012 - 2:23pm.

  10. Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine.

    ... lactate dehydrogenase , nor did they experience hemolysis or thrombosis , and they did not require specific ...

    Research Article last updated 10/11/2011 - 5:58pm.