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  1. Thrombosis in patients with paroxysmal nocturnal hemoglobinuria.

    ... hemoglobinuria is a disorder associated with hemolysis , pancytopenia , and thrombosis due to the loss of ... of thrombosis is multifactorial. Although intravascular hemolysis has been implicated as the etiology , the effect of ...

    Research Article last updated 10/11/2011 - 5:58pm.

  2. Chronic treatment of paroxysmal nocturnal hemoglobinuria patients with eculizumab: safety, efficacy, and unexpected laboratory phenomena

    ... duration of 16 months (range 6-46 months). Parameters of hemolysis , transfusion requirements, and serum iron parameters were ... of transfusion requirements, whereas other parameters of hemolysis remained abnormal. Six patients (31.6%) became completely transfusion ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria

    ... stem cells that is associated with hemolysis , marrow failure, and thrombophilia. PNH has been considered a ...

    Research Article last updated 10/02/2014 - 8:24am.

  4. Paroxysmal nocturnal hemoglobinuria clones in children with acquired aplastic anemia: a multicentre study

    ... a GPI-negative population >10%, and laboratory signs of hemolysis without hemoglobinuria were considered affected by ... size. In this study monitoring for laboratory signs of hemolysis was sufficient to diagnose PNH in AA patients. The presence of minor ...

    Research Article last updated 08/04/2014 - 8:16am.

  5. Understanding Hemolysis in PNH

    ... recorded in April 2012, Jamile Shammo presents on hemolysis in PNH. Link:  ... LMS Item Nesting:  Understanding Hemolysis in PNH/Understanding Hemolysis in PNH ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  6. Paroxysmal nocturnal hemoglobinuria in pediatric patients.

    ... PNH include: bone marrow failure , intravascular hemolysis , and thrombosis . To further characterize the clinical ... in all patients with AA, MDS, unexplained Coombs-negative hemolysis, or thrombosis. While HSCT remains the only curative option the high ...

    Research Article last updated 12/12/2011 - 10:07am.

  7. Efficacy and safety of eculizumab in children and adolescents with paroxysmal nocturnal hemoglobinuria

    ... with PNH frequently experience complications of chronic hemolysis , recurrent thrombosis , marrow failure, serious ... therapy resulted in complete and sustained inhibition of hemolysis in all participants with a reduction of lactate dehydrogenase ...

    Research Article last updated 05/22/2014 - 8:29am.

  8. Anti-Complement Treatment in Paroxysmal Nocturnal Hemoglobinuria: Where we Stand and Where we are Going

    ... a sustained control of complement-mediated intravascular hemolysis , with a remarkable clinical benefit. Anti-complement treatment ... patients receiving eculizumab, with adequate control of all hemolysis-associated symptoms even in almost all remaining patients. In ...

    Research Article last updated 05/22/2014 - 8:24am.

  9. Long term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival.

    ... mortality and morbidity due to intense intravascular hemolysis . Eculizumab , a monoclonal antibody against the complement protein C5, stops the intravascular hemolysis in PNH. We evaluated 79 consecutive patients treated with eculizumab ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemia.

    ... PNH clone size and the development of intravascular hemolysis , assessed by LDH values (Pearson Correlation Coefficient=0.80, ... granulocyte PNH size of 23% were the thresholds to predict hemolysis as measured by an elevated LDH (ROC analyses with AUC=0.96 for ...

    Research Article last updated 10/11/2011 - 5:58pm.