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  1. Phase I/II MEK162 Relapsed and/or Refractory Acute Myeloid Leukemia (AML) and Poor Prognosis, Not Suitable for or Unwilling to Receive Standard Therapy

    ... > 1.5 x ULN unless related to Gilbert's syndrome or hemolysis , AST and/or ALT > 2.5 X ULN, or for subjects with liver ...

    Clinical Trial last updated 06/06/2016 - 10:59am.

  2. A Trial to Evaluate Two Schedules of MS275 in Combination With 5AC in Elderly Patients With Acute Myeloid Leukemia (AML)

    ... bilirubin within institutional limits unless due to hemolysis , Gilbert's syndrome, or ineffective erythropoiesis. ...

    Clinical Trial last updated 06/03/2016 - 3:09pm.

  3. Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients

    ... C3, rendering such erythrocytes prone to extravascular hemolysis . This effect is associated with insufficient responsiveness seen ...

    Research Article last updated 04/29/2016 - 12:58pm.

  4. Impact of eculizumab treatment on paroxysmal nocturnal hemoglobinuria: A treatment versus no-treatment study

    ... Intravascular hemolysis in Paroxysmal nocturnal hemoglobinuria (PNH) can ...

    Research Article last updated 04/29/2016 - 10:21am.

  5. Phase I/II MAHCT w/ TCell Depleted Graft w/ Simultaneous Infusion Conventional and Regulatory T Cell

    ... may be included at the discretion of the PI or where hemolysis has been excluded Availability of an 6/6 HLA matched ...

    Clinical Trial last updated 05/09/2016 - 3:58pm.

  6. Disease Won't Run My Life

    ... to my PNH, my red blood cells had been merrily bursting ( hemolysis ), with no concern for me.  Occasionally, I was having PNH ...

    Patient Chronicle last updated 05/10/2016 - 3:36pm.

  7. Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders (BMT)

    ... bilirubin < 2.0 (unless diagnosis of Gilbert's or hemolysis is made) and AST, ALT, alkaline phosphatase all < 5x institutions ...

    Clinical Trial last updated 05/09/2016 - 3:36pm.

  8. Improved Fatigue and Quality-of-Life in Patients with Paroxysmal Nocturnal Hemoglobinuria During Treatment with Eculizumab: Data from the Global PNH Registry

    ... Paroxysmal nocturnal hemoglobinuria (PNH) causes hemolysis , or destruction of some or all of a patient’s red blood cells. This hemolysis and the other symptoms of PNH have a major impact on patients’ ...

    Research Review last updated 05/02/2016 - 9:21am.

  9. Novel Complement Modulators for Paroxysmal Nocturnal Hemoglobinuria: Peptide and Protein Inhibitors of C3 Convertase Prevent Both Surface C3 Deposition and Subsequent Hemolysis of Affected Erythrocytes in Vitro

    ... destroyed in the spleen. This is known as extravascular hemolysis . This study by a group in Italy examined two artificial ... that both of these proteins have the potential to turn off hemolysis, at least in the test tube. Because they both work at an early stage ...

    Research Review last updated 05/02/2016 - 9:25am.

  10. Eculizumab Protects Against TE and Prolongs Survival in Patients with Paroxysmal Nocturnal Hemoglobinuria: An International PNH Registry Study

    ... have shown that eculizumab (Soliris®) reduces rates of hemolysis , or the destruction of platelets, and thromboembolism. The ... Recent red blood cell transfusions, which can indicate hemolysis, were associated with a greater risk of thromboembolism. Not ...

    Research Review last updated 05/02/2016 - 9:26am.