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  1. Successful pregnancy outcome in paroxysmal nocturnal hemoglobinuria (PNH) following escalated eculizumab dosing to control breakthrough hemolysis

    ... , she became pregnant. She developed breakthrough hemolysis at 20 weeks gestation. Pharmacokinetic and pharmacodynamic ... Escalation of her eculizumab dose successfully controlled hemolysis and restored therapeutic eculizumab level and activity. She ...

    Research Article last updated 06/23/2015 - 9:29am.

  2. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... of PNH is chronic, complement-mediated, intravascular hemolysis , which results in anemia, hemoglobinuria, fatigue, and other hemolysis-related disabling symptoms. In addition, the peculiar thromboembolic ...

    Research Article last updated 03/05/2013 - 9:38am.

  3. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... of PNH is chronic, complement-mediated, intravascular hemolysis , which results in anemia, hemoglobinuria, fatigue, and other hemolysis-related disabling symptoms. In addition, the peculiar thromboembolic ...

    Research Article last updated 10/02/2012 - 9:57am.

  4. Paroxysmal Nocturnal Hemoglobinuria: A Complement-Mediated Hemolytic Anemia

    ... for thrombosis and marrow failure. The hemolysis is largely mediated by the alternative pathway of complement. ...

    Research Article last updated 06/23/2015 - 9:32am.

  5. Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review

    ... action of complement. Patients experience intravascular hemolysis , smooth muscle dystonia, renal failure, arterial and pulmonary ... of eculizumab , which brings benefits in terms of hemolysis, quality of life, renal function, thrombotic risk, and life ...

    Research Article last updated 04/07/2015 - 12:36pm.

  6. A prospective multicenter study of paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure.

    ... complement activation leading to intravascular hemolysis and an inflammatory prothrombotic state. The EXPLORE study aimed ... (BMF) syndromes and the effect of PNH clone size on hemolysis. METHODS: Patients, selected from medical office chart reviews, ...

    Research Article last updated 11/21/2013 - 11:54am.

  7. A Prospective Multicenter Study of Paroxysmal Nocturnal Hemoglobinuria Cells in Patients with Bone Marrow Failure.

    ... complement activation leading to intravascular hemolysis and an inflammatory prothrombotic state. The EXPLORE study aimed ... (BMF) syndromes and the effect of PNH clone size on hemolysis. Methods: Patients, selected from medical office chart reviews, had ...

    Research Article last updated 10/22/2013 - 3:42pm.

  8. Complement Blockade with a C1 Esterase Inhibitor in Paroxysmal Nocturnal Hemoglobinuria

    ... These patients experience both intra- and extravascular hemolysis in the context of underlying complement activation. Currently eculizumab effectively blocks the intravascular hemolysis PNH. There remains an unmet clinical need for a complement inhibitor ...

    Research Article last updated 08/04/2014 - 8:13am.

  9. Paroxysmal nocturnal hemoglobinuria and the age of therapeutic complement inhibition

    ... that result in both intravascular and extravascular hemolysis . Free hemoglobin leads to nitric oxide depletion ... drug that in PNH has been shown to block complement-mediated hemolysis, reduce transfusion dependency, reduce thromboembolic complications ...

    Research Article last updated 11/05/2013 - 12:37pm.

  10. Mechanisms and Clinical Implications of Thrombosis in Paroxysmal Nocturnal Hemoglobinuria

    ... CD55 and CD59 on erythrocytes leads to intravascular hemolysis upon complement activation. Next to hemolysis, another prominent feature is a highly increased risk of ...

    Research Article last updated 11/21/2011 - 3:08pm.