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  1. Allogeneic hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: a retrospective single-center study

    ... cell characterized by complement mediated intravascular hemolysis . There are different treatment modalities available for PNH, such ...

    Research Article last updated 11/02/2016 - 10:41am.

  2. Positive Impact of Eculizumab Therapy on Surgery for Budd-Chiari Syndrome in a Patient with Paroxysmal Nocturnal Hemoglobinuria and a Long-Term History of Thrombosis

    ... limited data on the use of eculizumab for prevention of hemolysis and its consequences in PNH patients undergoing surgery. Our ...

    Research Article last updated 11/02/2016 - 2:49pm.

  3. Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan

    ... outcomes included the reduction of intravascular hemolysis , the change in hemoglobin (Hb) level, the withdrawal of ... overall survival. The effect of eculizumab on intravascular hemolysis was demonstrated by a reduction in lactate dehydrogenase ...

    Research Article last updated 08/15/2016 - 9:10am.

  4. Paroxysmal Nocturnal Hemoglobinuria: The Future Of Complement-Based Therapies

    ... clinical benefit, making C3-mediated extravascular hemolysis the next challenge of PNH treatment. Indeed, a number of novel ... in clinical benefit by preventing C3-mediated extravascular hemolysis. These second-generation complement inhibitors include anti-C3 ...

    Research Article last updated 08/15/2016 - 9:11am.

  5. Eculizumab in the management of paroxysmal nocturnal hemoglobinuria: patient selection and special considerations

    ... hypertension, smooth muscle dysfunction, and chronic hemolysis . Until recently, treatment was mainly supportive with most ...

    Research Article last updated 09/13/2016 - 1:53pm.

  6. Fighting PNH While Helping PNH Patients

    ... platelet count had not been that bad… it was the hemolysis , resulting fatigue that had been the problem. For people who ...

    Patient Chronicle last updated 11/21/2016 - 12:47pm.

  7. Flu Season Update

    ... There are also a few case reports of incidents of hemolysis (when red blood cells are destroyed) after receiving a flu shot. ... are not the same as randomized clinical trials, one case of hemolysis was severe enough to put the patient in the hospital. Thus some ...

    Facts for Life last updated 02/01/2018 - 3:49pm.

  8. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... of PNH is chronic, complement-mediated, intravascular hemolysis , which results in anemia, hemoglobinuria, fatigue, and other hemolysis-related disabling symptoms. In addition, the peculiar thromboembolic ...

    Research Article last updated 03/05/2013 - 9:38am.

  9. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... of PNH is chronic, complement-mediated, intravascular hemolysis , which results in anemia, hemoglobinuria, fatigue, and other hemolysis-related disabling symptoms. In addition, the peculiar thromboembolic ...

    Research Article last updated 10/02/2012 - 9:57am.

  10. Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients

    ... C3, rendering such erythrocytes prone to extravascular hemolysis . This effect is associated with insufficient responsiveness seen ...

    Research Article last updated 04/29/2016 - 12:58pm.