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  1. Allogeneic hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: a retrospective single-center study

    ... cell characterized by complement mediated intravascular hemolysis . There are different treatment modalities available for PNH, such ...

    Research Article last updated 11/02/2016 - 10:41am.

  2. Positive Impact of Eculizumab Therapy on Surgery for Budd-Chiari Syndrome in a Patient with Paroxysmal Nocturnal Hemoglobinuria and a Long-Term History of Thrombosis

    ... limited data on the use of eculizumab for prevention of hemolysis and its consequences in PNH patients undergoing surgery. Our ...

    Research Article last updated 11/02/2016 - 2:49pm.

  3. Special Precautions

    ... a few case reports of PNH patients getting flares of hemolysis (when red blood cells are destroyed) after receiving a flu ... are not the same as randomized clinical trials, one case of hemolysis was severe enough to put the patient in the hospital. That is why ...

    Topic section last updated 09/08/2017 - 12:34pm.

  4. Antonio Maria Risitano, MD, PhD

    ... able to demonstrate that an additional mechanism of hemolysis may emerge during eculizumab treatment; it can be designated as "C3-mediated extravascular hemolysis.” They have subsequently extended their study, to provide possible ...

    Bio last updated 10/20/2017 - 9:50am.

  5. Eculizumab in the management of paroxysmal nocturnal hemoglobinuria: patient selection and special considerations

    ... hypertension, smooth muscle dysfunction, and chronic hemolysis . Until recently, treatment was mainly supportive with most ...

    Research Article last updated 09/13/2016 - 1:53pm.

  6. Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan

    ... outcomes included the reduction of intravascular hemolysis , the change in hemoglobin (Hb) level, the withdrawal of ... overall survival. The effect of eculizumab on intravascular hemolysis was demonstrated by a reduction in lactate dehydrogenase ...

    Research Article last updated 08/15/2016 - 9:10am.

  7. Paroxysmal Nocturnal Hemoglobinuria: The Future Of Complement-Based Therapies

    ... clinical benefit, making C3-mediated extravascular hemolysis the next challenge of PNH treatment. Indeed, a number of novel ... in clinical benefit by preventing C3-mediated extravascular hemolysis. These second-generation complement inhibitors include anti-C3 ...

    Research Article last updated 08/15/2016 - 9:11am.

  8. Fighting PNH While Helping PNH Patients

    ... platelet count had not been that bad… it was the hemolysis , resulting fatigue that had been the problem. For people who ...

    Patient Chronicle last updated 11/21/2016 - 12:47pm.

  9. Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients

    ... C3, rendering such erythrocytes prone to extravascular hemolysis . This effect is associated with insufficient responsiveness seen ...

    Research Article last updated 04/29/2016 - 12:58pm.

  10. Impact of eculizumab treatment on paroxysmal nocturnal hemoglobinuria: A treatment versus no-treatment study

    ... Intravascular hemolysis in Paroxysmal nocturnal hemoglobinuria (PNH) can ...

    Research Article last updated 04/29/2016 - 10:21am.