Search | Page 3 | Aplastic Anemia and MDS International Foundation

Search

Search results

  1. Thrombotic complications without evidence of hemolysis in paroxysmal nocturnal hemoglobinuria: is eculizumab indicated?

    ...

    Research Article last updated 07/31/2012 - 12:44pm.

  2. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... acquired disorder characterized by chronic intravascular hemolysis as the primary clinical manifestation and morbidities that ... platelets, resulting in complement-mediated intravascular hemolysis and other complications. Lysis of red blood cells is the most obvious ...

    Research Article last updated 05/14/2013 - 3:28pm.

  3. Fighting PNH While Helping PNH Patients

    ... platelet count had not been that bad… it was the hemolysis , resulting fatigue that had been the problem. For people who ...

    Patient Chronicle last updated 11/21/2016 - 12:47pm.

  4. Eculizumab in the management of paroxysmal nocturnal hemoglobinuria: patient selection and special considerations

    ... hypertension, smooth muscle dysfunction, and chronic hemolysis . Until recently, treatment was mainly supportive with most ...

    Research Article last updated 09/13/2016 - 1:53pm.

  5. Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan

    ... outcomes included the reduction of intravascular hemolysis , the change in hemoglobin (Hb) level, the withdrawal of ... overall survival. The effect of eculizumab on intravascular hemolysis was demonstrated by a reduction in lactate dehydrogenase ...

    Research Article last updated 08/15/2016 - 9:10am.

  6. Paroxysmal Nocturnal Hemoglobinuria: The Future Of Complement-Based Therapies

    ... clinical benefit, making C3-mediated extravascular hemolysis the next challenge of PNH treatment. Indeed, a number of novel ... in clinical benefit by preventing C3-mediated extravascular hemolysis. These second-generation complement inhibitors include anti-C3 ...

    Research Article last updated 08/15/2016 - 9:11am.

  7. Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients

    ... C3, rendering such erythrocytes prone to extravascular hemolysis . This effect is associated with insufficient responsiveness seen ...

    Research Article last updated 04/29/2016 - 12:58pm.

  8. Impact of eculizumab treatment on paroxysmal nocturnal hemoglobinuria: A treatment versus no-treatment study

    ... Intravascular hemolysis in Paroxysmal nocturnal hemoglobinuria (PNH) can ...

    Research Article last updated 04/29/2016 - 10:21am.

  9. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... of PNH is chronic, complement-mediated, intravascular hemolysis , which results in anemia, hemoglobinuria, fatigue, and other hemolysis-related disabling symptoms. In addition, the peculiar thromboembolic ...

    Research Article last updated 03/05/2013 - 9:38am.

  10. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... of PNH is chronic, complement-mediated, intravascular hemolysis , which results in anemia, hemoglobinuria, fatigue, and other hemolysis-related disabling symptoms. In addition, the peculiar thromboembolic ...

    Research Article last updated 10/02/2012 - 9:57am.