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  1. Improving cytopenia with splenic artery embolization in a patient with paroxysmal nocturnal hemoglobinuria on eculizumab

    ... stem cell disorder characterized by intravascular hemolysis , aplasia and an increased risk of thrombosis . We describe ...

    Research Article last updated 01/08/2014 - 9:53am.

  2. Long-term outcome of fludarabine-based reduced intensity allogeneic hematopoietic cell transplantation for debilitating paroxysmal nocturnal hemoglobinuria

    ... (PNH) is characterized by intravascular hemolysis , venous- thrombosis , and bone marrow failure . ...

    Research Article last updated 06/02/2014 - 11:39am.

  3. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... cells to break apart. Doctors call this breaking apart " hemolysis ." It happens because the surface of a person’s blood cells ... a few case reports of PNH patients getting flares of hemolysis (when red blood cells are destroyed) after receiving a flu shot. ...

    Page last updated 09/30/2017 - 11:34am.

  4. Assessing complement blockade in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab

    ... (PNH) is characterized by intravascular hemolysis , effectively controlled with eculizumab , a humanized ... during treatment. From 2010 to 2012, clinical data, hemolysis biomarkers, complement assessment and free eculizumab circulating ...

    Research Article last updated 01/20/2015 - 2:28pm.

  5. Thrombotic complications without evidence of hemolysis in paroxysmal nocturnal hemoglobinuria: is eculizumab indicated?

    Journal Title:  Ann Hematol Primary Author:  Bellido M Author(s):  Bellido M,...

    Research Article last updated 07/31/2012 - 12:44pm.

  6. Small-molecule Factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

    ... on eculizumab have symptomatic extravascular hemolysis , indicating an unmet need for additional therapeutic approaches. ... D inhibitors significantly reduced complement-mediated hemolysis at concentrations as low as 0.01 μΜ. Additionally the compound ...

    Research Article last updated 11/28/2016 - 11:42am.

  7. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... acquired disorder characterized by chronic intravascular hemolysis as the primary clinical manifestation and morbidities that ... platelets, resulting in complement-mediated intravascular hemolysis and other complications. Lysis of red blood cells is the most obvious ...

    Research Article last updated 05/14/2013 - 3:28pm.

  8. Paroxysmal Nocturnal Hemoglobinuria: From Bench to Bed

    ... of this disease arise as a result of complement-mediated hemolysis in unprotected red cells, leukocytes, and platelets as well as ...

    Research Article last updated 11/28/2016 - 11:40am.

  9. Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan

    ... outcomes included the reduction of intravascular hemolysis , the change in hemoglobin (Hb) level, the withdrawal of ... overall survival. The effect of eculizumab on intravascular hemolysis was demonstrated by a reduction in lactate dehydrogenase ...

    Research Article last updated 11/02/2016 - 10:39am.

  10. Pathogenesis of paroxysmal nocturnal hemoglobinuria

    ... deficient erythrocytes increase in proportion, massive hemolysis occurs due to activated complement attack during infection. As ...

    Research Article last updated 11/02/2016 - 2:52pm.