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  1. Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan

    ... outcomes included the reduction of intravascular hemolysis , the change in hemoglobin (Hb) level, the withdrawal of ... overall survival. The effect of eculizumab on intravascular hemolysis was demonstrated by a reduction in lactate dehydrogenase ...

    Research Article last updated 11/02/2016 - 10:39am.

  2. Pathogenesis of paroxysmal nocturnal hemoglobinuria

    ... deficient erythrocytes increase in proportion, massive hemolysis occurs due to activated complement attack during infection. As ...

    Research Article last updated 11/02/2016 - 2:52pm.

  3. Allogeneic hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: a retrospective single-center study

    ... cell characterized by complement mediated intravascular hemolysis . There are different treatment modalities available for PNH, such ...

    Research Article last updated 11/02/2016 - 10:41am.

  4. Positive Impact of Eculizumab Therapy on Surgery for Budd-Chiari Syndrome in a Patient with Paroxysmal Nocturnal Hemoglobinuria and a Long-Term History of Thrombosis

    ... limited data on the use of eculizumab for prevention of hemolysis and its consequences in PNH patients undergoing surgery. Our ...

    Research Article last updated 11/02/2016 - 2:49pm.

  5. Fighting PNH While Helping PNH Patients

    ... platelet count had not been that bad… it was the hemolysis , resulting fatigue that had been the problem. For people who ...

    Patient Chronicle last updated 11/21/2016 - 12:47pm.

  6. Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

    ... is characterized by complement-mediated intravascular hemolysis due to the lack of CD55 and CD59 on affected erythrocytes. The ... possibly leading to clinically meaningful extravascular hemolysis. We investigated the effect of the peptidic C3 inhibitor compstatin ...

    Research Article last updated 03/06/2014 - 11:17am.

  7. Clinical signs and symptoms associated with increased risk for thrombosis in patients with paroxysmal nocturnal hemoglobinuria from a Korean Registry.

    ... (PNH) is characterized by chronic, complement-mediated hemolysis , frequently leading to debilitating clinical symptoms and ... multivariate analysis showed that PNH patients with elevated hemolysis [ lactate dehydrogenase (LDH) levels ≥1.5 times the upper ...

    Research Article last updated 06/20/2013 - 11:07am.

  8. Improving cytopenia with splenic artery embolization in a patient with paroxysmal nocturnal hemoglobinuria on eculizumab

    ... stem cell disorder characterized by intravascular hemolysis , aplasia and an increased risk of thrombosis . We describe ...

    Research Article last updated 01/08/2014 - 9:53am.

  9. Long-term outcome of fludarabine-based reduced intensity allogeneic hematopoietic cell transplantation for debilitating paroxysmal nocturnal hemoglobinuria

    ... (PNH) is characterized by intravascular hemolysis , venous- thrombosis , and bone marrow failure . ...

    Research Article last updated 06/02/2014 - 11:39am.

  10. Assessing complement blockade in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab

    ... (PNH) is characterized by intravascular hemolysis , effectively controlled with eculizumab , a humanized ... during treatment. From 2010 to 2012, clinical data, hemolysis biomarkers, complement assessment and free eculizumab circulating ...

    Research Article last updated 01/20/2015 - 2:28pm.