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  1. Interviews with the Experts: Hemolysis in PNH and Beyond

    What is hemolysis and what its relationship to PNH? Hemolysis is a term we use to describe destruction and/or rupture of red blood ... In paroxysmal nocturnal hemoglobinuria (PNH), hemolysis occurs within the blood vessels and is typically induced by the ...

    Interview last updated 08/31/2016 - 8:40am.

  2. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... a life-threating disease characterized by intravascular hemolysis , bone marrow (BM) failure, and venous thrombosis . ...

    Research Article last updated 07/27/2017 - 2:06pm.

  3. Extravascular hemolysis and complement consumption in Paroxysmal Nocturnal Hemoglobinuria patients undergoing eculizumab treatment

    ... characterized by complement-mediated intravascular hemolysis that is effectively treated with eculizumab . However, ... heterogeneous with some patients presenting residual hemolysis and requiring RBC transfusions. Recent reports have shown that both ...

    Research Article last updated 10/06/2016 - 8:50am.

  4. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... a life-threating disease characterized by intravascular hemolysis , bone marrow (BM) failure, and venous thrombosis . ...

    Research Article last updated 07/11/2017 - 10:43am.

  5. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... cells to break apart. Doctors call this breaking apart " hemolysis ." It happens because the surface of a person’s blood cells ... a few case reports of PNH patients getting flares of hemolysis (when red blood cells are destroyed) after receiving a flu shot. ...

    Page last updated 09/30/2017 - 11:34am.

  6. A retrospective study of paroxysmal nocturnal hemoglobinuria in pediatric and adolescent patients

    ... especially in children, characterized by intravascular hemolysis , thrombotic events, serious infections and bone marrow ...

    Research Article last updated 05/02/2017 - 10:42am.

  7. Antonio Maria Risitano, MD, PhD

    ... able to demonstrate that an additional mechanism of hemolysis may emerge during eculizumab treatment; it can be designated as "C3-mediated extravascular hemolysis.” They have subsequently extended their study, to provide possible ...

    Bio last updated 10/20/2017 - 9:50am.

  8. Special Precautions

    ... a few case reports of PNH patients getting flares of hemolysis (when red blood cells are destroyed) after receiving a flu ... are not the same as randomized clinical trials, one case of hemolysis was severe enough to put the patient in the hospital. That is why ...

    Topic section last updated 09/08/2017 - 12:34pm.

  9. Update on the diagnosis and management of paroxysmal nocturnal hemoglobinuria

    ... by florid intravascular, complement-mediated hemolysis , whereas in others, bone marrow failure dominates the clinical picture with modest or even no evidence of hemolysis observed. The clinical heterogeneity is due to the close, though ...

    Research Article last updated 01/26/2017 - 11:03am.

  10. Small-molecule Factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

    ... on eculizumab have symptomatic extravascular hemolysis , indicating an unmet need for additional therapeutic approaches. ... D inhibitors significantly reduced complement-mediated hemolysis at concentrations as low as 0.01 μΜ. Additionally the compound ...

    Research Article last updated 11/28/2016 - 11:42am.