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  1. Eculizumab in the management of paroxysmal nocturnal hemoglobinuria: patient selection and special considerations

    ... Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal disorder resulting from ... Diseases:  paroxysmal nocturnal hemoglobinuria (PNH) ...

    Research Article last updated 09/13/2016 - 1:53pm.

  2. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... Paroxysmal nocturnal hemoglobinuria (PNH) is a hematological disorder characterized by ... intravascular hemolysis , which results in anemia, hemoglobinuria, fatigue, and other hemolysis-related disabling symptoms. In ...

    Research Article last updated 10/02/2012 - 9:57am.

  3. Diagnostic screening of paroxysmal nocturnal hemoglobinuria: Prospective multicentric evaluation of the current medical indications

    ... for the diagnostic screening of paroxysmal nocturnal hemoglobinuria (PNH) by flow cytometry (FCM), so far no study has ... for PNH screening included: hemolytic anemia (19%), hemoglobinuria (48%) and unexplained cytopenias (9%). In contrast, only a minor ...

    Research Article last updated 10/06/2016 - 8:56am.

  4. Extravascular hemolysis and complement consumption in Paroxysmal Nocturnal Hemoglobinuria patients undergoing eculizumab treatment

    ... Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia characterized ... Diseases:  paroxysmal nocturnal hemoglobinuria (PNH) ...

    Research Article last updated 10/06/2016 - 8:50am.

  5. Hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: long-term results of a retrospective study on behalf of the Gruppo Italiano Trapianto Midollo Osseo (GITMO).

    ... BACKGROUND: Paroxysmal nocturnal hemoglobinuria is an acquired clonal disorder of the hemopoietic stem ... and hematologic results in 26 paroxysmal nocturnal hemoglobinuria patients who received hematopoietic stem cell ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Multiparameter FLAER-based flow cytometry for screening of paroxysmal nocturnal hemoglobinuria enhances detection rates in patients with aplastic anemia

    ... methodology for screening of paroxysmal nocturnal hemoglobinuria . In the last few years, proaerolysin conjugated with ... panel used for the detection of paroxysmal nocturnal hemoglobinuria (PNH) clone . This study aimed to compare PNH clone ...

    Research Article last updated 01/20/2015 - 2:45pm.

  7. Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan

    ... eculizumab in patients with paroxysmal nocturnal hemoglobinuria (PNH) are limited. We describe the safety and effectiveness ... Diseases:  paroxysmal nocturnal hemoglobinuria (PNH) ...

    Research Article last updated 08/15/2016 - 9:10am.

  8. Performance characteristics of consensus approaches for small and minor paroxysmal nocturnal hemoglobinuria clone determination by flow cytometry.

    ... Abstract Background: Evaluation of paroxysmal nocturnal hemoglobinuria (PNH) clones by flow cytometry (FCM) is not ...

    Research Article last updated 07/09/2013 - 3:33pm.

  9. Management of thrombosis in paroxysmal nocturnal hemoglobinuria: a clinician's guide

    ... Diseases:  paroxysmal nocturnal hemoglobinuria (PNH) ...

    Research Article last updated 03/22/2017 - 2:43pm.

  10. Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

    ... Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare disease that has been investigated for ... Diseases:  paroxysmal nocturnal hemoglobinuria (PNH) ...

    Research Article last updated 06/07/2016 - 10:56am.