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  1. A retrospective study of paroxysmal nocturnal hemoglobinuria in pediatric and adolescent patients

    ... Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease, especially in children, ... Diseases:  paroxysmal nocturnal hemoglobinuria (PNH) ...

    Research Article last updated 05/02/2017 - 10:42am.

  2. Small-molecule Factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

    ... Paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome are diseases of ... and moreover some patients with paroxysmal nocturnal hemoglobinuria on eculizumab have symptomatic extravascular hemolysis , ...

    Research Article last updated 11/28/2016 - 11:42am.

  3. Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders

    ... damage in several human diseases. Paroxysmal nocturnal hemoglobinuria (PNH) may be considered the paradigm a disease caused by ... Diseases:  paroxysmal nocturnal hemoglobinuria (PNH) ...

    Research Article last updated 10/02/2012 - 10:00am.

  4. Eculizumab in Pregnant Patients with Paroxysmal Nocturnal Hemoglobinuria

    ... shown to prevent complications of paroxysmal nocturnal hemoglobinuria (PNH) and improve quality of life and overall survival, but ... Diseases:  paroxysmal nocturnal hemoglobinuria (PNH) ...

    Research Article last updated 10/12/2015 - 10:05am.

  5. Technical advances in flow cytometry-based diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria

    ... diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria for validation of high-sensitivity flow cytometry ... for diagnosis and/or monitoring of paroxysmal nocturnal hemoglobinuria. Results:: Implementation of technical advances reduced ...

    Research Article last updated 11/02/2016 - 10:42am.

  6. Update on the diagnosis and management of paroxysmal nocturnal hemoglobinuria

    ... Once suspected, the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) is straightforward when flow cytometric analysis of ... Diseases:  paroxysmal nocturnal hemoglobinuria (PNH) ...

    Research Article last updated 01/26/2017 - 11:03am.

  7. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... Paroxysmal nocturnal hemoglobinuria (PNH) is a hematological disorder characterized by ... intravascular hemolysis , which results in anemia, hemoglobinuria, fatigue, and other hemolysis-related disabling symptoms. In ...

    Research Article last updated 10/02/2012 - 9:57am.

  8. Bilateral central serous retinopathy in a patient with paroxysmal nocturnal hemoglobinuria treated with deferoxamine

    ... therapy in the context of paroxysmal nocturnal hemoglobinuria . METHODS: Spectral-domain optical coherence ... RESULTS: A 76-year-old man with paroxysmal nocturnal hemoglobinuria and hereditary spherocytosis was started on deferoxamine for ...

    Research Article last updated 11/02/2016 - 10:36am.

  9. Serologic response to meningococcal vaccination in patients with paroxysmal nocturnal hemoglobinuria (PNH) chronically treated with the terminal complement inhibitor eculizumab

    ... of patients with symptomatic paroxysmal nocturnal hemoglobinuria (PNH). Due to inhibition of terminal complement cascade, ... Diseases:  paroxysmal nocturnal hemoglobinuria (PNH) ...

    Research Article last updated 02/03/2017 - 11:21am.

  10. Hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: long-term results of a retrospective study on behalf of the Gruppo Italiano Trapianto Midollo Osseo (GITMO).

    ... BACKGROUND: Paroxysmal nocturnal hemoglobinuria is an acquired clonal disorder of the hemopoietic stem ... and hematologic results in 26 paroxysmal nocturnal hemoglobinuria patients who received hematopoietic stem cell ...

    Research Article last updated 10/11/2011 - 5:58pm.