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  1. Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia

    ... due to direct bone marrow involvement of disease Hemoglobin > 8.0 gm/dL, transfusion allowed Serum creatinine < 2.0 x ... donor has tested negative); testing for the presence of hemoglobin S is not required DONOR: Positive infectious disease test as ...

    Clinical Trial last updated 06/13/2016 - 3:31pm.

  2. Genetic Polymorphism of the Complement Receptor-1 (CR1) Gene Correlates with the Clinical Response to Eculizumab of Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... with PNH who go on Eculizumab have an increase in their hemoglobin up to the normal range and never require another transfusion. Other patients will have an increase in their hemoglobin and will be able to discontinue transfusions, but will still be ...

    Research Review last updated 05/02/2016 - 9:25am.

  3. What is a complete blood count test (CBC)?

    ... is red blood cells. This number is about 3 times the hemoglobin . Platelet count measures the number of ... 10,000 (4.5 to 10) thousand cells/mcL Hemoglobin Male 13.8 to 17.2 grams/dL Female 12.0 to ...

    FAQ last updated 04/28/2016 - 4:53pm.

  4. Interviews with the Experts: The Complement System in PNH

    ... the holes and pores on the cell surface, releasing the hemoglobin inside the cell through the holes –  the hemoglobin escapes the cell walls. This is the point where hemolysis ...

    Interview last updated 08/31/2016 - 8:39am.

  5. Fludarabine/Clofarabine/Busulfan Combined With SAHA in Acute Leukemia

    ... FVC and DLCO at least 45% of expected corrected for hemoglobin . Children unable to perform pulmonary functions must have an ...

    Clinical Trial last updated 06/06/2016 - 11:07am.

  6. What are the different components of blood?

    ... up almost half of blood. Red blood cells are filled with hemoglobin . That's a protein that picks up oxygen in the lungs and brings ...

    FAQ last updated 04/28/2016 - 4:19pm.

  7. A Pilot, Phase I/II Study of the Amino Acid Leucine in the Treatment of Patients With Transfusion-Dependent Diamond Blackfan Anemia (LeucineDBA)

    ... a capsule and will be taken three times daily. Blood hemoglobin levels will be monitored every 3-4 weeks for 9 months. The ...

    Clinical Trial last updated 04/28/2016 - 8:40am.

  8. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... sustained control of intravascular hemolysis, leading to hemoglobin stabilization and transfusion independence in more than ...

    Research Article last updated 03/05/2013 - 9:38am.

  9. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... sustained control of intravascular hemolysis, leading to hemoglobin stabilization and transfusion independence in more than ...

    Research Article last updated 10/02/2012 - 9:57am.

  10. A Phase III, International, Randomized, Controlled Study of Rigosertib versus Physician’s Choice of Treatment in Patients with Myelodysplastic Syndrome after Failure of a Hypomethylating Agent

    ... < 1800/L or platelet count < 100,000/L or hemoglobin [Hgb] <10 g/dL) d.  Progression (according to 2006 IWG ...

    Clinical Trial last updated 11/29/2016 - 8:29am.