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  1. Genetic and epigenetic pathways in myelodysplastic syndromes: A brief overview

    ... The major clinical features of MDS are ineffective hematopoiesis , peripheral cytopenias, and an increased risk of ...

    Research Article last updated 01/20/2015 - 12:59pm.

  2. Bone marrow mesenchymal stem cells from aplastic anemia patients preserve functional and immune properties and do not contribute to the pathogenesis of the disease

    ... properties and their ability to support hematopoiesis , and they have been involved in the pathogenesis of several ...

    Research Article last updated 04/23/2014 - 10:09am.

  3. Total Lymphoid Irradiation-Antithymocyte Globulin Conditioning and Allogeneic Transplantation for Patients with Myelodysplastic Syndromes and Myeloproliferative Neoplasms

    ... globulin (ATG) permits the establishment of donor hematopoiesis necessary for the graft-versus-malignancy effect and is ...

    Research Article last updated 04/17/2014 - 11:48am.

  4. Should elderly patients with higher-risk myelodysplastic syndromes undergo allogeneic hematopoietic stem cell transplantation?

    ... characterized by dysplastic changes, ineffective hematopoiesis and variable risk of leukemic progression. At diagnosis, 86% ...

    Research Article last updated 10/22/2013 - 3:12pm.

  5. Epigenetics in focus: Pathogenesis of myelodysplastic syndromes and the role of hypomethylating agents

    ... may reprogram the "methylome" while re-establishing hematopoiesis . Bone Marrow Diseases:  ...

    Research Article last updated 08/06/2013 - 2:48pm.

  6. Combination of Azacitidine and Lenalidomide in Myelodysplastic Syndromes or acute Myeloid Leukemia-a wise Liaison?

    ... the positive effects of each drug on the defective hematopoiesis while sparing potential side effects and toxicities. ...

    Research Article last updated 06/20/2013 - 11:05am.

  7. Immunomodulatory Drugs: New Options for the Treatment of Myelodysplastic Syndromes

    ... adult hematologic disorders characterized by ineffective hematopoiesis with progressive cytopenia and a risk of evolving ...

    Research Article last updated 01/03/2013 - 9:57am.

  8. Emerging immunosuppressive drugs in myelodysplastic syndromes

    ... by dysplastic morphologic features and ineffective hematopoiesis . Pathophysiological characteristics change over time making ...

    Research Article last updated 01/03/2013 - 9:54am.

  9. Interpreting new molecular genetics in myelodysplastic syndromes

    ... group of clonal diseases characterized by ineffective hematopoiesis , peripheral blood cytopenias, and an increased risk of ...

    Research Article last updated 01/02/2013 - 2:59pm.

  10. Myelodysplastic syndrome hematopoietic stem cell

    ... (HSC) malignancies that are characterized by ineffective hematopoiesis and frequent progression to acute myeloid leukemia (AML). ...

    Research Article last updated 11/05/2012 - 10:21am.