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  1. Myelodysplastic syndromes: What do hospitalists need to know?

    ... cell disorders characterized by dysplasia, ineffective hematopoiesis leading to peripheral blood cytopenias, and a variable risk ...

    Research Article last updated 06/20/2013 - 10:59am.

  2. Clinical and biological implications of driver mutations in myelodysplastic syndromes.

    ... malignancies characterized by dysplasia, ineffective hematopoiesis and a variable risk of progression to acute myeloid leukemia. ...

    Research Article last updated 09/17/2013 - 1:37pm.

  3. A systematic modeling study on the pathogenic role of p38 MAPK activation in myelodysplastic syndromes

    ... hematopoietic cells are associated with the ineffective hematopoiesis in MDS. However, the molecular mechanism of p38 MAPK ... phenomenon commonly observed in MDS, and lead to ineffective hematopoiesis. Our study suggests that the combination of molecular biological ...

    Research Article last updated 06/15/2012 - 1:19pm.

  4. More is better: Combination therapies for myelodysplastic syndromes

    ... (WHO). They are characterized by ineffective hematopoiesis , subsequent cytopenias, transformation to acute myeloid ...

    Research Article last updated 03/03/2015 - 2:41pm.

  5. The complex pathophysiology of acquired aplastic anemia

    ... to immune mediated killing of HSPCs and/or ineffective hematopoiesis . Although the inciting autoantigens remain elusive, ...

    Research Article last updated 03/03/2015 - 11:32am.

  6. Clinical utility of lenalidomide in the treatment of myelodysplastic syndromes

    ... paradoxical BM hypercellularity, ineffective hematopoiesis , and increased risk of leukemic transformation. Risk ...

    Research Article last updated 03/02/2015 - 2:11pm.

  7. Genetic and epigenetic pathways in myelodysplastic syndromes: A brief overview

    ... The major clinical features of MDS are ineffective hematopoiesis , peripheral cytopenias, and an increased risk of ...

    Research Article last updated 01/20/2015 - 12:59pm.

  8. Bone marrow mesenchymal stem cells from aplastic anemia patients preserve functional and immune properties and do not contribute to the pathogenesis of the disease

    ... properties and their ability to support hematopoiesis , and they have been involved in the pathogenesis of several ...

    Research Article last updated 04/23/2014 - 10:09am.

  9. Total Lymphoid Irradiation-Antithymocyte Globulin Conditioning and Allogeneic Transplantation for Patients with Myelodysplastic Syndromes and Myeloproliferative Neoplasms

    ... globulin (ATG) permits the establishment of donor hematopoiesis necessary for the graft-versus-malignancy effect and is ...

    Research Article last updated 04/17/2014 - 11:48am.

  10. Should elderly patients with higher-risk myelodysplastic syndromes undergo allogeneic hematopoietic stem cell transplantation?

    ... characterized by dysplastic changes, ineffective hematopoiesis and variable risk of leukemic progression. At diagnosis, 86% ...

    Research Article last updated 10/22/2013 - 3:12pm.