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  1. Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide

    ... affecting CD34+ cells, characterized by ineffective hematopoiesis , often transforming into acute myelogenous leukemia ...

    Research Article last updated 04/17/2014 - 11:29am.

  2. Stem cell origin of myelodysplastic syndromes

    ... by decreased blood counts due to ineffective hematopoiesis . MDS is considered a 'preleukemic' disorder linked to a ...

    Research Article last updated 01/08/2014 - 9:05am.

  3. Reduced ribosomal RNA expression and increased ribosomal DNA promoter methylation in CD34+ cells of patients with myelodysplastic syndromes

    ... stem cells characterized by ineffective hematopoiesis . The DNA hypomethylating agents 5-azacytidine (5AC) and ... in decreased rRNA synthesis that may contribute to defective hematopoiesis and BMF in some individuals with MDS. ...

    Research Article last updated 11/05/2012 - 9:58am.

  4. Myelodysplastic syndromes: What do hospitalists need to know?

    ... cell disorders characterized by dysplasia, ineffective hematopoiesis leading to peripheral blood cytopenias, and a variable risk ...

    Research Article last updated 06/20/2013 - 10:59am.

  5. A systematic modeling study on the pathogenic role of p38 MAPK activation in myelodysplastic syndromes

    ... hematopoietic cells are associated with the ineffective hematopoiesis in MDS. However, the molecular mechanism of p38 MAPK ... phenomenon commonly observed in MDS, and lead to ineffective hematopoiesis. Our study suggests that the combination of molecular biological ...

    Research Article last updated 06/15/2012 - 1:19pm.

  6. Clinical and biological implications of driver mutations in myelodysplastic syndromes.

    ... malignancies characterized by dysplasia, ineffective hematopoiesis and a variable risk of progression to acute myeloid leukemia. ...

    Research Article last updated 09/17/2013 - 1:37pm.

  7. Pathogenesis of MDS: An Overview of molecular and non-molecular aspects of the disease

    ... stem cells generally characterized by inefficient hematopoiesis , dysplasia in one or more myeloid cell lineages, and ...

    Research Article last updated 05/12/2015 - 9:47am.

  8. More is better: Combination therapies for myelodysplastic syndromes

    ... (WHO). They are characterized by ineffective hematopoiesis , subsequent cytopenias, transformation to acute myeloid ...

    Research Article last updated 03/03/2015 - 2:41pm.

  9. The complex pathophysiology of acquired aplastic anemia

    ... to immune mediated killing of HSPCs and/or ineffective hematopoiesis . Although the inciting autoantigens remain elusive, ...

    Research Article last updated 03/03/2015 - 11:32am.

  10. Clinical utility of lenalidomide in the treatment of myelodysplastic syndromes

    ... paradoxical BM hypercellularity, ineffective hematopoiesis , and increased risk of leukemic transformation. Risk ...

    Research Article last updated 03/02/2015 - 2:11pm.