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  1. Analysis of allogeneic hematopoietic stem cell transplantation with high-dose cyclophosphamide-induced immune tolerance for severe aplastic anemia

    ... was confirmed by the evidence of 100 % donor hematopoiesis ; T lymphocyte subset counts also increased ...

    Research Article last updated 11/01/2016 - 1:59pm.

  2. Clinical outcome after failure of hypomethylating therapy for myelodysplastic syndromes

    ... affect older patients, are characterized by ineffective hematopoiesis in one or more lineages of the bone marrow . In the ...

    Research Article last updated 03/03/2015 - 12:40pm.

  3. Myelodysplastic syndromes: pathophysiology, clinical and biological features

    ... or more myeloid lineages responsible for an ineffective hematopoiesis , and therefore cytopenias of central origin contrasting with ...

    Research Article last updated 04/29/2016 - 11:32am.

  4. Unraveling Myelodysplastic Syndromes: Current Knowledge and Future Directions

    ... prognoses. The main features of MDS are ineffective hematopoiesis and aberrant myeloid differentiation. Furthermore, MDS are ...

    Research Article last updated 04/29/2016 - 11:23am.

  5. Pathogenesis of myelodysplastic syndromes: an overview of molecular and non-molecular aspects of the disease

    ... stem cells generally characterized by inefficient hematopoiesis , dysplasia in one or more myeloid cell lineages, and ...

    Research Article last updated 01/20/2015 - 12:52pm.

  6. Epigenetic regulation in myelodysplastic syndromes: implications for therapy.

    ... syndromes (MDS), characterized by ineffective hematopoiesis and dysplasia in one or more lineages, produce ... can 're-programme' gene expression patterns of abnormal hematopoiesis in MDS. Recently FDA-approved DNA-methyltransferase inhibitors, ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Targeting immune dysregulation in myelodysplastic syndromes.

    ... bone marrow disorders characterized by ineffective hematopoiesis and a tendency to develop leukemia. In some patients, ... of cytotoxic CD8(+) T cells that suppress normal hematopoiesis, as well as expansion of CD4(+) helper T-cell subsets that ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. When to treat myelodysplastic syndromes.

    ... characterized by morphologic dysplasia, aberrant hematopoiesis and a variable risk of progression to acute myeloid leukemia. These syndromes have a complex pathobiology, and ineffective hematopoiesis is a well-recognized feature of all of them. Normal blood cell ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. Myelodysplastic syndromes: where do we go from here?

    ... characterized by morphologic dysplasia, aberrant hematopoiesis and a variable risk of progression to acute myeloid leukemia. These syndromes have a complex pathobiology, and ineffective hematopoiesis is a well-recognized feature of all of them. Normal blood cell ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. Tricking or treating myelodysplastic syndromes.

    ... characterized by morphologic dysplasia, aberrant hematopoiesis and a variable risk of progression to acute myeloid leukemia. These syndromes have a complex pathobiology, and ineffective hematopoiesis is a well-recognized feature of all of them. Normal blood cell ...

    Research Article last updated 10/11/2011 - 5:58pm.