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  1. Hematopoietic Stem Cell Regulation by Type I and II Interferons in the Pathogenesis of Acquired Aplastic Anemia

    ... A comprehensive understanding of how interferons impact hematopoiesis is necessary in order to identify novel therapeutic ...

    Research Article last updated 10/06/2016 - 9:44am.

  2. Pexmetinib: a novel dual inhibitor of Tie-2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia

    ... of primary MDS specimens with this compound stimulated hematopoiesis . Our results provide preclinical proof of concept for ...

    Research Article last updated 07/18/2016 - 11:12am.

  3. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... Formed? The process of making blood cells is called hematopoiesis . Blood cells are made in the bone marrow , a spongy tissue ...

    Page last updated 09/30/2017 - 11:34am.

  4. Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia.

    ... a substantial proportion of AA patients harbors clonal hematopoiesis characterized by the presence of acquired copy number-neutral ... of AA patients. These findings indicate that the 6pLOH(+) hematopoiesis found in AA represents 'escape' hematopoiesis from the ...

    Research Article last updated 10/12/2011 - 3:13pm.

  5. Myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms: an update on risk stratification, molecular genetics, and therapeutic approaches including allogeneic hematopoietic stem cell transplantation

    ... stem cell disorders characterized by ineffective hematopoiesis , peripheral cytopenias, and a variable propensity for ...

    Research Article last updated 06/22/2015 - 10:15am.

  6. Clinical outcome after failure of hypomethylating therapy for myelodysplastic syndromes

    ... affect older patients, are characterized by ineffective hematopoiesis in one or more lineages of the bone marrow . In the ...

    Research Article last updated 03/03/2015 - 12:40pm.

  7. Pathogenesis of myelodysplastic syndromes: an overview of molecular and non-molecular aspects of the disease

    ... stem cells generally characterized by inefficient hematopoiesis , dysplasia in one or more myeloid cell lineages, and ...

    Research Article last updated 01/20/2015 - 12:52pm.

  8. Plasma circulating-microRNA profiles are useful for assessing prognosis in patients with cytogenetically normal myelodysplastic syndromes

    ... stem cell disorders characterized by ineffective hematopoiesis and peripheral cytopenias. Chromosomal abnormalities and ...

    Research Article last updated 09/24/2014 - 10:41am.

  9. Epigenetic regulation in myelodysplastic syndromes: implications for therapy.

    ... syndromes (MDS), characterized by ineffective hematopoiesis and dysplasia in one or more lineages, produce ... can 're-programme' gene expression patterns of abnormal hematopoiesis in MDS. Recently FDA-approved DNA-methyltransferase inhibitors, ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. Targeting immune dysregulation in myelodysplastic syndromes.

    ... bone marrow disorders characterized by ineffective hematopoiesis and a tendency to develop leukemia. In some patients, ... of cytotoxic CD8(+) T cells that suppress normal hematopoiesis, as well as expansion of CD4(+) helper T-cell subsets that ...

    Research Article last updated 10/11/2011 - 5:58pm.