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  1. Pathogenesis of myelodysplastic syndromes: an overview of molecular and non-molecular aspects of the disease

    ... stem cells generally characterized by inefficient hematopoiesis , dysplasia in one or more myeloid cell lineages, and ...

    Research Article last updated 01/20/2015 - 12:52pm.

  2. Plasma circulating-microRNA profiles are useful for assessing prognosis in patients with cytogenetically normal myelodysplastic syndromes

    ... stem cell disorders characterized by ineffective hematopoiesis and peripheral cytopenias. Chromosomal abnormalities and ...

    Research Article last updated 09/24/2014 - 10:41am.

  3. Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide

    ... affecting CD34+ cells, characterized by ineffective hematopoiesis , often transforming into acute myelogenous leukemia ...

    Research Article last updated 04/17/2014 - 11:29am.

  4. Epigenetic regulation in myelodysplastic syndromes: implications for therapy.

    ... syndromes (MDS), characterized by ineffective hematopoiesis and dysplasia in one or more lineages, produce ... can 're-programme' gene expression patterns of abnormal hematopoiesis in MDS. Recently FDA-approved DNA-methyltransferase inhibitors, ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Targeting immune dysregulation in myelodysplastic syndromes.

    ... bone marrow disorders characterized by ineffective hematopoiesis and a tendency to develop leukemia. In some patients, ... of cytotoxic CD8(+) T cells that suppress normal hematopoiesis, as well as expansion of CD4(+) helper T-cell subsets that ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. When to treat myelodysplastic syndromes.

    ... characterized by morphologic dysplasia, aberrant hematopoiesis and a variable risk of progression to acute myeloid leukemia. These syndromes have a complex pathobiology, and ineffective hematopoiesis is a well-recognized feature of all of them. Normal blood cell ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Myelodysplastic syndromes: where do we go from here?

    ... characterized by morphologic dysplasia, aberrant hematopoiesis and a variable risk of progression to acute myeloid leukemia. These syndromes have a complex pathobiology, and ineffective hematopoiesis is a well-recognized feature of all of them. Normal blood cell ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Tricking or treating myelodysplastic syndromes.

    ... characterized by morphologic dysplasia, aberrant hematopoiesis and a variable risk of progression to acute myeloid leukemia. These syndromes have a complex pathobiology, and ineffective hematopoiesis is a well-recognized feature of all of them. Normal blood cell ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. Stem cell origin of myelodysplastic syndromes

    ... by decreased blood counts due to ineffective hematopoiesis . MDS is considered a 'preleukemic' disorder linked to a ...

    Research Article last updated 01/08/2014 - 9:05am.

  10. Reduced ribosomal RNA expression and increased ribosomal DNA promoter methylation in CD34+ cells of patients with myelodysplastic syndromes

    ... stem cells characterized by ineffective hematopoiesis . The DNA hypomethylating agents 5-azacytidine (5AC) and ... in decreased rRNA synthesis that may contribute to defective hematopoiesis and BMF in some individuals with MDS. ...

    Research Article last updated 11/05/2012 - 9:58am.