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  1. Analysis of allogeneic hematopoietic stem cell transplantation with high-dose cyclophosphamide-induced immune tolerance for severe aplastic anemia

    ... was confirmed by the evidence of 100 % donor hematopoiesis ; T lymphocyte subset counts also increased ...

    Research Article last updated 11/01/2016 - 1:59pm.

  2. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... Formed? The process of making blood cells is called hematopoiesis . Blood cells are made in the bone marrow , a spongy tissue ...

    Page last updated 09/30/2017 - 11:34am.

  3. Deregulated microRNA expression and its pathogenetic implications for myelodysplastic syndromes

    ... stem cell disorders characterized by ineffective hematopoiesis , cytopenias. MicroRNAs (miRNAs) are short non-coding RNA ...

    Research Article last updated 08/15/2016 - 11:30am.

  4. Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure

    ... the hierarchical organization of malignant clones in the hematopoiesis of myelodysplastic syndromes (MDS) and its impact on ...

    Research Article last updated 07/18/2016 - 11:18am.

  5. Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes

    ... of their capabilities of immunomodulatory and supporting hematopoiesis . Nevertheless, it is unclear whether the characteristics of ... appeared to be impaired in immunomodulatory and supporting hematopoiesis function. Although, MDS-MSCs could express hematopoietic ...

    Research Article last updated 04/24/2012 - 2:10pm.

  6. Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

    ... that are characterized by defective bone marrow hematopoiesis and by the occurrence of intramedullary apoptosis . ... that the dysregulation of these molecules leads to abnormal hematopoiesis, unbalanced cell death and proliferation in patients' bone marrow ...

    Research Article last updated 04/29/2016 - 11:35am.

  7. Hematopoietic Stem Cell Regulation by Type I and II Interferons in the Pathogenesis of Acquired Aplastic Anemia

    ... A comprehensive understanding of how interferons impact hematopoiesis is necessary in order to identify novel therapeutic ...

    Research Article last updated 10/06/2016 - 9:44am.

  8. Myelodysplastic syndromes: pathophysiology, clinical and biological features

    ... or more myeloid lineages responsible for an ineffective hematopoiesis , and therefore cytopenias of central origin contrasting with ...

    Research Article last updated 04/29/2016 - 11:32am.

  9. Unraveling Myelodysplastic Syndromes: Current Knowledge and Future Directions

    ... prognoses. The main features of MDS are ineffective hematopoiesis and aberrant myeloid differentiation. Furthermore, MDS are ...

    Research Article last updated 04/29/2016 - 11:23am.

  10. Pexmetinib: a novel dual inhibitor of Tie-2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia

    ... of primary MDS specimens with this compound stimulated hematopoiesis . Our results provide preclinical proof of concept for ...

    Research Article last updated 07/18/2016 - 11:12am.