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  1. Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

    ... that are characterized by defective bone marrow hematopoiesis and by the occurrence of intramedullary apoptosis . ... that the dysregulation of these molecules leads to abnormal hematopoiesis, unbalanced cell death and proliferation in patients' bone marrow ...

    Research Article last updated 04/29/2016 - 11:35am.

  2. Hematopoietic Stem Cell Regulation by Type I and II Interferons in the Pathogenesis of Acquired Aplastic Anemia

    ... A comprehensive understanding of how interferons impact hematopoiesis is necessary in order to identify novel therapeutic ...

    Research Article last updated 10/06/2016 - 9:44am.

  3. Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes

    ... of their capabilities of immunomodulatory and supporting hematopoiesis . Nevertheless, it is unclear whether the characteristics of ... appeared to be impaired in immunomodulatory and supporting hematopoiesis function. Although, MDS-MSCs could express hematopoietic ...

    Research Article last updated 04/24/2012 - 2:10pm.

  4. Pexmetinib: a novel dual inhibitor of Tie-2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia

    ... of primary MDS specimens with this compound stimulated hematopoiesis . Our results provide preclinical proof of concept for ...

    Research Article last updated 07/18/2016 - 11:12am.

  5. Myelodysplastic syndromes: pathophysiology, clinical and biological features

    ... or more myeloid lineages responsible for an ineffective hematopoiesis , and therefore cytopenias of central origin contrasting with ...

    Research Article last updated 04/29/2016 - 11:32am.

  6. Unraveling Myelodysplastic Syndromes: Current Knowledge and Future Directions

    ... prognoses. The main features of MDS are ineffective hematopoiesis and aberrant myeloid differentiation. Furthermore, MDS are ...

    Research Article last updated 04/29/2016 - 11:23am.

  7. Myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms: an update on risk stratification, molecular genetics, and therapeutic approaches including allogeneic hematopoietic stem cell transplantation

    ... stem cell disorders characterized by ineffective hematopoiesis , peripheral cytopenias, and a variable propensity for ...

    Research Article last updated 06/22/2015 - 10:15am.

  8. Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia.

    ... a substantial proportion of AA patients harbors clonal hematopoiesis characterized by the presence of acquired copy number-neutral ... of AA patients. These findings indicate that the 6pLOH(+) hematopoiesis found in AA represents 'escape' hematopoiesis from the ...

    Research Article last updated 10/12/2011 - 3:13pm.

  9. Clinical outcome after failure of hypomethylating therapy for myelodysplastic syndromes

    ... affect older patients, are characterized by ineffective hematopoiesis in one or more lineages of the bone marrow . In the ...

    Research Article last updated 03/03/2015 - 12:40pm.

  10. Pathogenesis of myelodysplastic syndromes: an overview of molecular and non-molecular aspects of the disease

    ... stem cells generally characterized by inefficient hematopoiesis , dysplasia in one or more myeloid cell lineages, and ...

    Research Article last updated 01/20/2015 - 12:52pm.