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  1. A systematic modeling study on the pathogenic role of p38 MAPK activation in myelodysplastic syndromes

    ... hematopoietic cells are associated with the ineffective hematopoiesis in MDS. However, the molecular mechanism of p38 MAPK ... phenomenon commonly observed in MDS, and lead to ineffective hematopoiesis. Our study suggests that the combination of molecular biological ...

    Research Article last updated 06/15/2012 - 1:19pm.

  2. Eltrombopag now an approved therapy for certain patients with severe aplastic anemia

    ... According to Cynthia Dunbar, M.D., Head, Molecular Hematopoiesis Section, Hematology Branch, Division of Intramural Research, ...

    Page last updated 08/27/2014 - 2:19pm.

  3. Targeting immune dysregulation in myelodysplastic syndromes.

    ... bone marrow disorders characterized by ineffective hematopoiesis and a tendency to develop leukemia. In some patients, ... of cytotoxic CD8(+) T cells that suppress normal hematopoiesis, as well as expansion of CD4(+) helper T-cell subsets that ...

    Research Article last updated 10/11/2011 - 5:58pm.

  4. Epigenetic regulation in myelodysplastic syndromes: implications for therapy.

    ... syndromes (MDS), characterized by ineffective hematopoiesis and dysplasia in one or more lineages, produce ... can 're-programme' gene expression patterns of abnormal hematopoiesis in MDS. Recently FDA-approved DNA-methyltransferase inhibitors, ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Myelodysplastic syndromes: where do we go from here?

    ... characterized by morphologic dysplasia, aberrant hematopoiesis and a variable risk of progression to acute myeloid leukemia. These syndromes have a complex pathobiology, and ineffective hematopoiesis is a well-recognized feature of all of them. Normal blood cell ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Tricking or treating myelodysplastic syndromes.

    ... characterized by morphologic dysplasia, aberrant hematopoiesis and a variable risk of progression to acute myeloid leukemia. These syndromes have a complex pathobiology, and ineffective hematopoiesis is a well-recognized feature of all of them. Normal blood cell ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. When to treat myelodysplastic syndromes.

    ... characterized by morphologic dysplasia, aberrant hematopoiesis and a variable risk of progression to acute myeloid leukemia. These syndromes have a complex pathobiology, and ineffective hematopoiesis is a well-recognized feature of all of them. Normal blood cell ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Myelodysplastic syndrome hematopoietic stem cell

    ... (HSC) malignancies that are characterized by ineffective hematopoiesis and frequent progression to acute myeloid leukemia (AML). ...

    Research Article last updated 11/05/2012 - 10:21am.

  9. Last Marrow Standing: Bone Marrow Transplantation for Acquired Bone Marrow Failure Conditions

    ... immune dysregulation and the development of abnormal hematopoiesis . Allogeneic hematopoietic cell transplantation plays a ...

    Research Article last updated 11/05/2012 - 10:06am.

  10. Immunomodulatory treatment of myelodysplastic syndromes: antithymocyte globulin, cyclosporine, and alemtuzumab

    ... forms of IST have been successfully used to restore hematopoiesis in MDS in many centers worldwide. In this review we outline ...

    Research Article last updated 11/05/2012 - 9:48am.