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  1. Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia

    ... destruction of early hematopoietic cells. Clonal hematopoiesis is a late complication, seen in 20-25% of older patients. We hypothesized that clonal hematopoiesis in aAA is a more general phenomenon, which can arise early in ...

    Research Article last updated 04/07/2015 - 1:05pm.

  2. Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

    ... acquired during human aging. Clonally restricted hematopoiesis is associated with an increased risk of subsequent diagnosis ... morphology of blood and marrow cells, and clonal hematopoiesis, most individuals who acquire clonal hematopoiesis during aging ...

    Research Article last updated 06/03/2015 - 1:38pm.

  3. Clonal hematopoiesis in acquired aplastic anemia

    ... Clonal hematopoiesis (CH) in aplastic anemia (AA) has been closely linked ...

    Research Article last updated 06/22/2016 - 10:18am.

  4. Progress in Myelodysplastic Syndromes: Clinicopathologic Correlations and Immune Checkpoints

    ... a group of clonal neoplasms characterized by ineffective hematopoiesis . Hypomethylating agent (HMA) therapy is one of the mainstays ... MDS, the immune system has a pivotal role in modulation of hematopoiesis and clonal expansion. In neoplastic conditions, immune checkpoint ...

    Research Article last updated 09/11/2017 - 8:59am.

  5. Early treatment initiation in lower-risk myelodysplastic syndromes produces an earlier and higher rate of transfusion independence

    ... syndromes (MDS) are characterized by ineffective hematopoiesis resulting in refractory cytopenias. Red blood ...

    Research Article last updated 09/13/2017 - 8:58am.

  6. The microenvironment in myelodysplastic syndromes: niche-mediated disease initiation and progression

    ... of acquired marrow failure. Hallmarked by ineffective hematopoiesis , dysplastic marrow, and risk of transformation to acute ...

    Research Article last updated 09/13/2017 - 8:25am.

  7. A call for action: Increasing enrollment of untreated patients with higher-risk myelodysplastic syndromes in first-line clinical trials.

    ... syndromes (HR-MDS). HMAs have improved hematopoiesis and quality of life and, in the case of azacitidine , ...

    Research Article last updated 09/11/2017 - 9:04am.

  8. Foundation Update - August 2017

    ... by NIH to study the effects of DNA damage accrual in hematopoiesis . In the last few years, Dr. Batista has built on his initial ...

    Article last updated 09/05/2017 - 10:53am.

  9. Marrow protein may be key to SCT success

    ... cells, including immune cells, in a process known as hematopoiesis . A new study led by University of Pennsylvania and ...

    Article last updated 08/29/2017 - 11:18am.

  10. Top honor goes to AAMDSIF Medical Advisor

    ... myeloma. Recent studies have characterized clonal hematopoiesis and its contribution to both hematologic malignancies and ... Award, and the International Society for Experimental Hematopoiesis Till and McCullough Award. “The Society is honored ...

    Article last updated 08/29/2017 - 7:54am.