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  1. Long-term Survival and Late Effects among 1-year Survivors of Second Allogeneic Hematopoietic Cell Transplantation for Relapsed Acute Leukemia and Myelodysplastic Syndromes

    ... We analyzed the outcomes of patients who survived disease-free for 1-year or more following second allogeneic hematopoietic cell ... remission prior to second HCT, P<0.01). Chronic graft-versus-host disease (GVHD) developed in 43% and 75% of children and ...

    Research Article last updated 10/27/2014 - 9:31am.

  2. Cotransplantation of allogeneic mesenchymal and hematopoietic stem cells in children with aplastic anemia

    ... antithymocyte globulin with or without busulfan. Graft-versus-host disease (GvHD) was prevented by the administration of cyclosporine ...

    Research Article last updated 07/30/2012 - 1:18pm.

  3. Allogeneic hematopoietic cell transplantation in patients with myelodysplastic syndromes

    ... However, the main drawbacks of this procedure, including graft-versus-host disease (GVHD) and hematologic relapse, remain a challenge in daily patient ...

    Research Article last updated 11/05/2012 - 9:30am.

  4. Hematopoietic stem cell transplantation in children and young adults with secondary myelodysplastic syndrome and acute myeloid leukemia following aplastic anemia

    ... . The cumulative incidence of grade II-IV acute graft-versus-host disease (GVHD) was 47%, and that of chronic GVHD was 70%. Relapse occurred ...

    Research Article last updated 01/07/2014 - 12:37pm.

  5. Transplantation strategies for the management of patients with myelodysplastic syndromes.

    ... due primarily to TRM in patients with low-risk MDS and to disease recurrence in patients with high-risk MDS. Allogeneic SCT from matched ... in patient populations, preparative regimens, and graft-versus-host disease (GvHD) prophylaxis, as well as donor source ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. A randomized comparison of cyclophosphamide vs. reduced dose cyclophosphamide plus fludarabine for allogeneic hematopoietic cell transplantation in patients with aplastic anemia and hypoplastic myelodysplastic syndrome.

    ... failure (2.5 vs. 2.33 %; p = 0.959), acute graft-versus-host disease (GvHD) (15.0 vs. 23.3 %; p = 0.388), and chronic GvHD (16.7 vs. ...

    Research Article last updated 05/11/2012 - 2:04pm.

  7. Comparison of Outcomes after Transplantation of G-CSF-Stimulated Bone Marrow Grafts versus Bone Marrow or Peripheral Blood Grafts from HLA-Matched Sibling Donors for Patients with Severe Aplastic Anemia.

    ... not different among the 3 treatment groups. Grade 2-4 acute graft-versus-host disease (aGVHD) (relative risk [RR] = 0.82, P = .539), grade 3-4 aGVHD (RR = ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. REVERSE 1 INCB 18424-271

    ... for the Treatment of Steroid- Refractory Acute Graft-Versus-Host Disease - The purpose of this study is to assess the efficacy of ruxolitinib in ...

    Clinical Trial last updated 12/14/2016 - 11:24am.

  9. A Phase 1, Multicenter, Open-Label, Dose-Escalation and Expansion, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-120 in Subjects with Advanced Hematologic Malignancies with an IDH1 Mutation

    ... Fri, 06/30/2017 Bone Marrow Disease(s):  acute myeloid leukemia (AML) ... at the time of screening, or with clinically significant graft-versus-host disease (GVHD) . (The use of a stable dose of oral ...

    Clinical Trial last updated 02/22/2017 - 11:21am.

  10. Graft-vs-host-disease (GVHD): Signs, Symptoms, and Treatment

    ... cells ( stem cells ) donated by someone else. Graft-versus-host disease (GVHD) is a common, and sometimes serious, side effect of an ...

    LMS Item last updated 06/10/2016 - 1:24pm.