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  1. First-in Human Clinical Transplant Trial for Severe Aplastic Anemia

    ... study got us started, showing that we could have a high engraftment rate with a low GVHD rate, and a surprisingly high survival ... be able to prevent rejection, which will allow for faster engraftment than would occur with either a haplo or standard cord blood ...

    Interview last updated 10/04/2017 - 1:36pm.

  2. Haploidentical transplantation for pediatric patients with acquired severe aplastic anemia

    ... globulin . Fifty-one patients achieved primary engraftment ; one child died of regimen-related toxicity on the day +1. ...

    Research Article last updated 01/24/2017 - 11:52am.

  3. Analysis of allogeneic hematopoietic stem cell transplantation with high-dose cyclophosphamide-induced immune tolerance for severe aplastic anemia

    ... reconstitution was achieved in 17 cases and engraftment after a second transplantation in an additional three cases. The average times to engraftment were 17.4 and 21.3 days, respectively, with neutrophils ≥0.5 × 109/L and platelets ≥20 × 109/L. Engraftment was confirmed by the evidence of 100 % donor hematopoiesis ...

    Research Article last updated 11/01/2016 - 1:59pm.

  4. Alternative Donor Transplantation with High-Dose Post-Transplantation Cyclophosphamide for Refractory Severe Aplastic Anemia

    ... days was 19 (range, 16 to 27) days, to red cell engraftment was 25 (range, 2 to 58) days, and to last platelet ... appears promising in refractory SAA patients. Importantly, engraftment was 100%, pre-existing clonal disease was eradicated, and the risk ...

    Research Article last updated 01/24/2017 - 10:04am.

  5. Comparable outcomes between younger (⩽40 years) and older (>40 years) adult patients with severe aplastic anemia after HLA-matched sibling stem cell transplantation using fludarabine-based conditioning

    ... primary graft failure was observed. Neutrophil engraftment was significantly faster in the YAG compared with the OAG (12 ...

    Research Article last updated 11/28/2016 - 9:28am.

  6. Marrow grafts from HLA-identical siblings for severe aplastic anemia: does limiting the number of transplanted marrow cells reduce the risk of chronic GvHD?

    ... of the patients rejected the graft, all had sustained engraftment and all are surviving at a median of 4 (range 1-8) years after ...

    Research Article last updated 09/13/2016 - 12:50pm.

  7. Excellent Outcome of Haploidentical Hematopoietic Stem Cell Transplantation in Children and Adolescents with Acquired Severe Aplastic Anemia

    ... Among the 12 patients, 11 achieved neutrophil engraftment at a median of 10 days (range, 9 to 13 days) after HHCT. One patient failed to achieve primary engraftment, and two experienced graft rejection soon after engraftment. All ...

    Research Article last updated 03/05/2013 - 8:11am.

  8. 7-year-old Little Mermaid fan gets her BMT

    ... weekly visits to the hospital to monitor Yasmin's cell engraftment level. Right now, it's at 100 percent. This means her new cell ...

    Article last updated 06/14/2016 - 11:52am.

  9. Allogeneic stem cell transplantation for myelodysplastic syndromes with bone marrow fibrosis.

    ... those with severe fibrosis (n=39) and analyzed regarding engraftment , treatment-related mortality, relapse and survival. RESULTS: ... abnormal cytogenetics . The cumulative incidence of engraftment achieved at day +30 in non-fibrotic patients was 93% and was ...

    Research Article last updated 07/28/2014 - 8:21am.

  10. Allogeneic stem cell transplantation using alemtuzumab-containing regimens in severe aplastic anemia.

    ... used to reduce graft-versus- host disease (GVHD) and aid engraftment after allogeneic haemopoietic stem cell transplant ... in SAA and show that it results in sustained haematological engraftment, a very low incidence of chronic GVHD without an increase in viral ...

    Research Article last updated 06/20/2013 - 10:30am.