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  1. Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant

    ... donors (MRDs) for HSCT. The median times for myeloid engraftment in the HID and MRD cohorts were 12 (range, 9-20) and 11 (range, ... status pre-SCT. We did not observe differences in primary engraftment and survival outcomes by donor type. CONCLUSIONS: ...

    Research Article last updated 02/03/2017 - 9:40am.

  2. Excellent Outcome of Haploidentical Hematopoietic Stem Cell Transplantation in Children and Adolescents with Acquired Severe Aplastic Anemia

    ... Among the 12 patients, 11 achieved neutrophil engraftment at a median of 10 days (range, 9 to 13 days) after HHCT. One patient failed to achieve primary engraftment, and two experienced graft rejection soon after engraftment. All ...

    Research Article last updated 03/05/2013 - 8:11am.

  3. Analysis of allogeneic hematopoietic stem cell transplantation with high-dose cyclophosphamide-induced immune tolerance for severe aplastic anemia

    ... reconstitution was achieved in 17 cases and engraftment after a second transplantation in an additional three cases. The average times to engraftment were 17.4 and 21.3 days, respectively, with neutrophils ≥0.5 × 109/L and platelets ≥20 × 109/L. Engraftment was confirmed by the evidence of 100 % donor hematopoiesis ...

    Research Article last updated 11/01/2016 - 1:59pm.

  4. Haploidentical transplantation for pediatric patients with acquired severe aplastic anemia

    ... globulin . Fifty-one patients achieved primary engraftment ; one child died of regimen-related toxicity on the day +1. ...

    Research Article last updated 01/24/2017 - 11:52am.

  5. Alternative Donor Transplantation with High-Dose Post-Transplantation Cyclophosphamide for Refractory Severe Aplastic Anemia

    ... days was 19 (range, 16 to 27) days, to red cell engraftment was 25 (range, 2 to 58) days, and to last platelet ... appears promising in refractory SAA patients. Importantly, engraftment was 100%, pre-existing clonal disease was eradicated, and the risk ...

    Research Article last updated 01/24/2017 - 10:04am.

  6. Comparable outcomes between younger (⩽40 years) and older (>40 years) adult patients with severe aplastic anemia after HLA-matched sibling stem cell transplantation using fludarabine-based conditioning

    ... primary graft failure was observed. Neutrophil engraftment was significantly faster in the YAG compared with the OAG (12 ...

    Research Article last updated 11/28/2016 - 9:28am.

  7. Allogeneic stem cell transplantation for myelodysplastic syndromes with bone marrow fibrosis.

    ... those with severe fibrosis (n=39) and analyzed regarding engraftment , treatment-related mortality, relapse and survival. RESULTS: ... abnormal cytogenetics . The cumulative incidence of engraftment achieved at day +30 in non-fibrotic patients was 93% and was ...

    Research Article last updated 07/28/2014 - 8:21am.

  8. Allogeneic stem cell transplantation using alemtuzumab-containing regimens in severe aplastic anemia.

    ... used to reduce graft-versus- host disease (GVHD) and aid engraftment after allogeneic haemopoietic stem cell transplant ... in SAA and show that it results in sustained haematological engraftment, a very low incidence of chronic GVHD without an increase in viral ...

    Research Article last updated 06/20/2013 - 10:30am.

  9. Marrow grafts from HLA-identical siblings for severe aplastic anemia: does limiting the number of transplanted marrow cells reduce the risk of chronic GvHD?

    ... of the patients rejected the graft, all had sustained engraftment and all are surviving at a median of 4 (range 1-8) years after ...

    Research Article last updated 09/13/2016 - 12:50pm.

  10. Hematopoietic stem cell transplantation with umbilical cord multipotent stromal cell infusion for the treatment of aplastic anemia-a single-center experience.

    ... monoclonal antibody was performed. Hematopoietic engraftment , the occurrence of graft-versus-host disease (GVHD) and ... were documented. RESULTS: All patients had rapid engraftment; mean time for neutrophil and platelet recovery was ...

    Research Article last updated 07/09/2013 - 2:48pm.