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  1. Thrombosis in paroxysmal nocturnal hemoglobinuria.

    ... and endothelial dysfunction. Complement inhibition with eculizumab generally has a dramatic effect in PNH and has a major impact in ...

    Research Article last updated 05/14/2013 - 3:29pm.

  2. A closer look at paroxysmal nocturnal hemoglobinuria

    ... development of the novel targeted therapeutic agent eculizumab has offered new promises for this highly morbid and fatal ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. Long-term outcome of fludarabine-based reduced intensity allogeneic hematopoietic cell transplantation for debilitating paroxysmal nocturnal hemoglobinuria

    ... option for PNH patients who are not candidates for eculizumab treatment. Bone ...

    Research Article last updated 06/02/2014 - 11:39am.

  4. Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine.

    ... specific interventions with anticoagulation and/or eculizumab . Of the 7 patients who did require therapy for clinical ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... targeting the terminal complement protein C5 ( Eculizumab ), anticoagulation, and in some cases allogeneic HSC transplant. ...

    Research Article last updated 10/22/2013 - 3:44pm.

  6. Paroxysmal nocturnal hemoglobinuria in pediatric patients.

    ... Three patients received anti-complement therapy with eculizumab . Two patients died following complications related to thrombosis ...

    Research Article last updated 12/12/2011 - 10:07am.

  7. Selective splenic artery embolization for the treatment of thrombocytopenia and hypersplenism in paroxysmal nocturnal hemoglobinuria

    ... One patient, who had had only a partial response to eculizumab , responded to SSAE not only with an improved platelet count, ... red cells in patients who have had a limited response to eculizumab, resulting in an improved quality of life for selected patients. ...

    Research Article last updated 04/17/2014 - 1:34pm.

  8. Paroxysmal nocturnal hemoglobinuria from bench to bedside

    ... GPI-anchor and serves as a novel reagent diagnosing PNH. Eculizumab , a humanized monoclonal antibody against C5, is the ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... to additional complications, such as thrombosis. Eculizumab , a humanized monoclonal antibody against the C5 ...

    Research Article last updated 05/14/2013 - 3:28pm.

  10. Cerebral venous thrombosis in paroxysmal nocturnal hemoglobinuria: a series of 15 cases and review of the literature

    ... did not have bone marrow transplantation or eculizumab therapy. Cases of death were mainly related to hepatic vein ...

    Research Article last updated 03/02/2015 - 11:38am.