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  1. Combined intensive immunosuppression and eculizumab for aplastic anemia in the context of hemolytic paroxysmal nocturnal hemoglobinuria: a retrospective analysis

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    Research Article last updated 12/06/2017 - 8:46am.

  2. Eculizumab in Pregnant Patients with Paroxysmal Nocturnal Hemoglobinuria

    ... BACKGROUND: Eculizumab , a humanized monoclonal antibody against complement ... of life and overall survival, but data on the use of eculizumab in women during pregnancy are scarce. METHODS: We ...

    Research Article last updated 10/12/2015 - 10:05am.

  3. Eculizumab

    Eculizumab (Soliris ®) is given as an IV into a vein at the doctor’s ... Some common side effects of eculizumab include: Headache Tiredness Nausea and vomiting ... The data provided on eculizumab is for informational purposes only. It is not intended to be ...

    Topic section last updated 03/29/2016 - 7:20pm.

  4. Assessing complement blockade in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab

    ... hemolysis , effectively controlled with eculizumab , a humanized monoclonal antibody that binds complement ... data, hemolysis biomarkers, complement assessment and free eculizumab circulating levels were systematically measured immediately prior ...

    Research Article last updated 01/20/2015 - 2:28pm.

  5. Polymorphism of the complement receptor 1 gene correlates with hematological response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria

    ... Complement blockade by eculizumab is clinically effective in hemolytic Paroxysmal Nocturnal ... with hemolytic Paroxysmal Nocturnal Hemoglobinuria on eculizumab we tested the hypothesis that response may depend on genetic ...

    Research Article last updated 09/26/2013 - 3:28pm.

  6. Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan

    ... Data characterizing the safety and effectiveness of eculizumab in patients with paroxysmal nocturnal hemoglobinuria ... are limited. We describe the safety and effectiveness of eculizumab in PNH patients enrolled in a post-marketing surveillance study. ...

    Research Article last updated 11/02/2016 - 10:39am.

  7. Positive Impact of Eculizumab Therapy on Surgery for Budd-Chiari Syndrome in a Patient with Paroxysmal Nocturnal Hemoglobinuria and a Long-Term History of Thrombosis

    ... plasma lactate dehydrogenase ; he started eculizumab therapy with a good response. In October 2012, he developed ... At the time of writing, the patient remains stable and eculizumab continues to be effective. There is limited data on the use of ...

    Research Article last updated 11/02/2016 - 2:49pm.

  8. Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan

    ... Data characterizing the safety and effectiveness of eculizumab in patients with paroxysmal nocturnal hemoglobinuria ... are limited. We describe the safety and effectiveness of eculizumab in PNH patients enrolled in a post-marketing surveillance study. ...

    Research Article last updated 08/15/2016 - 9:10am.

  9. Extravascular hemolysis and complement consumption in Paroxysmal Nocturnal Hemoglobinuria patients undergoing eculizumab treatment

    ... hemolysis that is effectively treated with eculizumab . However, treatment responses are reported heterogeneous with ... suboptimal hematological responses. Here we have tested our eculizumab-treated PNH patients (n=12) for signs of hemolysis and assessed ...

    Research Article last updated 10/06/2016 - 8:50am.

  10. Impact of eculizumab treatment on paroxysmal nocturnal hemoglobinuria: A treatment versus no-treatment study

    ... (PNH) can effectively be controlled with eculizumab , a humanized monoclonal antibody that binds complement ... comparison study between 123 patients treated with eculizumab in the recent period (>2005) and 191 historical controls (from the ...

    Research Article last updated 04/29/2016 - 10:21am.