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  1. Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN)/Myelodysplastic Syndrome (MDS)

    ... and improving constitutional symptoms. Low dose decitabine has demonstrated depletion of DNMT1 in normal hematopoietic ... . Furthermore, the low toxicity associated with low dose decitabine would allow for more frequent (1 to 3 times weekly) administration ...

    Clinical Trial last updated 04/29/2016 - 1:59pm.

  2. Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia

    ... hydrochloride and cytarabine when followed by decitabine or observation in treating older patients with newly diagnosed ... as clofarabine, daunorubicin hydrochloride, cytarabine, and decitabine, work in different ways to stop the growth of cancer cells, either ...

    Clinical Trial last updated 04/28/2016 - 12:10pm.

  3. Cladribine Plus Low Dose Cytarabine (LDAC) Alternating With Decitabine in Patients With Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)

    ... given in combination with low-dose cytarabine (LDAC) and decitabine can help control the disease in patients with AML or MDS. The ... to stop them from growing and repairing themselves. Decitabine is designed to damage the DNA of cells, which may cause cancer cells ...

    Clinical Trial last updated 04/29/2016 - 12:17pm.

  4. Genomic Predictors of Decitabine Response in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes

    ... leukemia or myelodysplastic syndromes respond to decitabine . This study will contribute to the efforts to find effective and ... Associated Drug(s):  Decitabine Phase:  Phase 2 ...

    Clinical Trial last updated 04/29/2016 - 12:30pm.

  5. Study of Vosaroxin and Decitabine in Older Patients With Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome

    ... study is to learn if the combination of vosaroxin and decitabine can help to control AML or MDS. The safety of these drugs will ... Associated Drug(s):  Decitabine Phase:  Phase 1 ...

    Clinical Trial last updated 04/29/2016 - 11:49am.

  6. Pharmacokinetic Guided Dose Escalation and Dose Confirmation With Oral Decitabine and Oral CDAi in Patients With MDS

    ... Associated Drug(s):  Decitabine Phase:  Phase 1 ... Escalation Oral investigational product and approved IV decitabine Other Names: E7727 oral decitabine IV decitabine Drug: ASTX727 ...

    Clinical Trial last updated 04/27/2016 - 2:05pm.

  7. MDS Drug Therapy

    ... and high-risk patients with all sub-types of MDS Decitabine (Dacogen®) for both low- and high-risk patients with all ... Decitabine (Dacogen®) Decitabine ...

    Topic section last updated 03/10/2016 - 11:26pm.

  8. San Diego Family Takes Action for Awareness

    ... the three FDA approved drugs, azacitidine , decitabine , and lenalidomide – noting of course that the latter ...

    Patient Chronicle last updated 10/26/2016 - 11:42am.

  9. Selinexor (KPT-330) in Older Patients With Relapsed/Refractory AML (SOPRA)

    ... (i) BSC alone, (ii) BSC plus either azacytidine or decitabine or (iii) BSC plus low-dose Ara-C. Overall survival is the ... Azacitidine Decitabine Selinexor (KPT-330) ...

    Clinical Trial last updated 08/26/2016 - 9:21am.

  10. Clinical Trials Report for April 2016

    ... agent (HMA), azacitidine (AZA) or decitabine (DEC). This study is being conducted in IL, MD, NY, ...

    Page last updated 08/10/2016 - 11:00am.