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  1. Therapy-related myelodysplastic syndromes, or are they?

    ... monotherapy, biologically and clinically resemble de novo (d)-MDS more than t-MDS, and therefore may not be truly ...

    Research Article last updated 01/26/2017 - 10:08am.

  2. Association of Therapy for Autoimmune Disease With Myelodysplastic Syndromes and Acute Myeloid Leukemia

    ... 72.3 [15.6] years), 55 (64.0%) had MDS, 21 (24.4%) had de novo AML, and 10 (11.6%) had AML and a history of MDS. Rheumatoid arthritis ...

    Research Article last updated 02/03/2017 - 1:25pm.

  3. Clinical features and prognosis of patients with myelodysplastic syndromes who were exposed to atomic bomb radiation in Nagasaki

    ... (P = 0.0001, and P < 0.0001, respectively). As with de novo MDS, multivariate Cox regression analyses revealed that cytogenetic ...

    Research Article last updated 11/02/2016 - 9:24am.

  4. Prognostic pre-transplant factors in myelodysplastic syndromes primarily treated by high dose allogeneic hematopoietic stem cell transplantation: a retrospective study of the MDS subcommittee of the CMWP of the EBMT

    ... Author(s):  Cremers EM, van Biezen A, de Wreede LC, Scholten M, Vitek A, Finke J, Platzbecker U, Beelen D, ... obtain a homogeneous patient cohort by including only de novo MDS patients who received upfront allogeneic SCT after standard high ...

    Research Article last updated 10/06/2016 - 11:40am.

  5. Clinical Effects of Driver Somatic Mutations on the Outcomes of Patients With Myelodysplastic Syndromes Treated With Allogeneic Hematopoietic Stem-Cell Transplantation

    ... in genes of RNA splicing machinery, TP53-mutated AML, or de novo AML) was an independent predictor of posttransplantation outcome (P = ...

    Research Article last updated 10/06/2016 - 3:00pm.

  6. Top expert calls future MDS/AML care “promising”

    ... both patients who present with either high- or low-risk de novo , and patients who have actually been treated with these ...

    Article last updated 11/02/2016 - 11:28am.

  7. Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases

    ... leukemia (t-AML); and compared these findings with de novo MDS/AML. Consecutive bone marrow samples of 498 patients, ...

    Research Article last updated 03/02/2015 - 2:00pm.

  8. Causes

    ... De Novo MDS The cause of most MDS cases is ...

    Topic section last updated 03/10/2016 - 10:59pm.

  9. CASCADE (SGN33A-005)

    ... untreated, cytologically/histologically confirmed de novo or secondary AML according to World Health Organization (WHO) ...

    Clinical Trial last updated 06/19/2017 - 2:43pm.

  10. Oral Azacitidine (CC-486) for the Treatment of Myelodysplastic Syndromes and Acute Myeloid Leukemia

    ... to acute myeloid leukemia (AML). AML, which can occur de novo as well as secondary to MDS, is characterized by malignant clones of ...

    Research Article last updated 12/09/2015 - 8:49am.