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  1. Response to azacitidine is independent of p53 expression in higher-risk myelodysplastic syndromes and secondary acute myeloid leukemia.

    ... patients were p53-positive and most had very poor risk cytogenetics with chromosome 5 aberrations and monosomal karyotypes. The ...

    Research Article last updated 07/07/2014 - 9:27am.

  2. Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine.

    ... Performance status ≥ 2, intermediate- and poor-risk cytogenetics , presence of circulating blasts, and red blood cell ...

    Research Article last updated 07/28/2014 - 8:53am.

  3. Cutting edge: flow cytometry in myelodysplastic syndromes

    ... syndromes (MDS), especially when cytomorphology and cytogenetics are inconclusive. Minimal requirements to analyze dysplasia ...

    Research Article last updated 08/06/2013 - 12:05pm.

  4. SF3B1 mutations in patients with myelodysplastic syndromes: the mutation is stable during disease evolution

    ... counts, lower lactate dehydrogenase levels, good-risk cytogenetics and mutations of DNMT3A, but inversely related to ASXL1 ...

    Research Article last updated 04/23/2014 - 11:18am.

  5. Improving the diagnosis and treatment of patients with myelodysplastic syndromes through a performance improvement initiative

    ... careful consideration of pathologic features and cytogenetics , and treatment options vary based on disease severity. A ...

    Research Article last updated 02/08/2013 - 7:53am.

  6. SNP array-based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes.

    ... polymorphism (SNP) arrays, complementing routine cytogenetics . We hypothesized that clinically important cryptic clonal ... in 5/14 (36%) patients with normal/non-informative routine cytogenetics. In a subset of AA patients studied at presentation, persistent ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Standardizing the Initial Evaluation for Myelodysplastic Syndromes.

    ... using laboratory results, morphology and cytogenetics . More sophisticated technologies, including multi-color ...

    Research Article last updated 11/05/2013 - 12:31pm.

  8. Revised International Prognostic Scoring System (IPSS) Predicts Survival and Leukemic Evolution of Myelodysplastic Syndromes Significantly Better Than IPSS and WHO Prognostic Scoring System: Validation by the Gruppo Romano Mielodisplasie Italian Regional

    ... and bone marrow counts, informative cytogenetics , and follow-up data.ResultsWe validated the IPSS-R score as a ...

    Research Article last updated 08/07/2013 - 9:18am.

  9. Transplantation for myelodysplastic syndromes 2013.

    ... relapse-free survival even in patients with high-risk cytogenetics . The optimal stem cell source may differ for different patient ...

    Research Article last updated 10/22/2013 - 12:53pm.

  10. Recent advances in the management of therapy-related myelodysplastic syndromes and acute myeloid leukemia.

    ... Multiple retrospective studies have identified poor-risk cytogenetics , chemotherapy resistance, comorbidities from prior ...

    Research Article last updated 02/04/2013 - 2:51pm.